Can two immune boosters beat advanced melanoma?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: * Histologic diagnosis of malignant melanoma (MEL) * Measurable unresectable Stage III or IV MEL * ECOG performance status score of 0 or 1 * Life expectancy ≥4 months * For those enrolled in amendment 5 and later, tumor tissue (archival or recent acquisition) must be available * For Cohorts 1-5, subjects may have been treated with up to 3 prior systemic standard treatments for metastatic melanoma not including any post-incisional adjuvant therapy. Subjects may be treatment naïve. All metastatic melanoma regardless of primary site of disease will be allowed * For Cohorts 6-7, subjects may have been treated with up to 3 prior systemic standard treatments for metastatic melanoma; this does not include any post-incisional adjuvant therapy. Specifically, subjects must have received ≥3 doses of Ipilimumab therapy and the last dose having been administered within 4-12 weeks of initiation of study treatment Exclusion Criteria: * History of severe hypersensitivity reactions to other mAbs * Prior malignancy active within the previous 2 years except for localized cancers that are considered to have been cured and in the opinion of the investigator present a low risk for recurrence * Active autoimmune disease or a history of known or suspected autoimmune disease * History of recently active diverticulitis or symptomatic peptic ulcer disease and history of adrenal insufficiency * Regular narcotic analgesia * Active, untreated central nervous system metastasis * For subjects enrolled in Cohorts 1-5, prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137 or anti-CTLA-4 antibody * For subjects enrolled in Cohorts 6-7, prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CD137 antibodies * Any non-oncology vaccine therapy used for prevention of infectious disease * Concomitant therapy with any other anti-cancer therapy, concurrent medical conditions requiring use of immunosuppressive medications or use of other investigational drugs * Positive tests for human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), hepatitis B, hepatitis C * Subjects weighing ≥125 kg are excluded from Cohort 5 * Subjects in Cohorts 6 and 7 must have received Ipilimumab monotherapy immediately prior to study entry, but must not have received that Ipilimumab as part of a clinical trial * Subjects with ocular melanoma are excluded from Cohort 8