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Immunotherapy after chemo shows promise for elderly brain cancer patients

NCT ID NCT04022980

First seen Jan 10, 2026 · Last updated May 21, 2026 · Updated 25 times

Summary

This early-phase study tested whether the immunotherapy drug nivolumab could safely improve outcomes for people aged 65 and older with primary central nervous system lymphoma (a rare brain cancer). After completing initial high-dose chemotherapy, 14 participants received nivolumab to help their immune system fight any remaining cancer cells. The goal was to find a safe dose and see if it could delay the cancer from coming back.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Brookline, Massachusetts, 02215, United States

  • Levine Cancer Institute

    Charlotte, North Carolina, 28204, United States

  • The University of Texas - MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • UNC Hospitals, The University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27514, United States

Conditions

Explore the condition pages connected to this study.