Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Laughing gas studied for pain relief: early results show promise?

NCT ID NCT01581450

Knowledge-focused Sponsor: Air Liquide Santé International Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This completed Phase 1 study tested whether 35% nitrous oxide (laughing gas) can reduce pain sensitivity in 20 healthy men. Researchers used electrical stimulation to create temporary pain and measured how the gas affected the area of increased sensitivity. The study also monitored vital signs and sedation levels to check safety.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nitrous oxide (laughing gas)
What this could lead to
If successful, this could help understand how nitrous oxide affects pain sensitivity, potentially guiding future pain treatments.
What could go wrong
This is a very early, small study in healthy volunteers, not patients. Results may not apply to real-world pain conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

20 people

The number who actually took part.

Start date

Jan 2012

Finished

Apr 2012

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Caucasian healthy male * Able to feel a distinct pin-pick sensation on normal skin * Subject willing and able to complete the requirements of this study * Written informed consent signed prior to any study related procedures Exclusion Criteria: * History of any past or current renal, hepatic, cardiovascular, pulmonary, gastrointestinal, metabolic, endocrine haematological, neurological, psychiatric disease or other disorders * Any significant history of allergic disease * Acute skin disease, lesions, acute sunburn, extensive tattoos or scars * Donation of blood within the previous 3 months * participation in any other clinical study within the previous 4 weeks.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Hyperalgesia are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Hyperalgesia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hyperalgesia

Contacts and locations

Locations

  • University of Erlangen - Nürnberg

    Erlangen, 91054, Germany

  • University of Erlangen - Nürnberg

    Erlangen, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.