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Can a gas protect your kidneys during heart surgery?

NCT ID NCT06622291

Disease control Sponsor: Beijing Anzhen Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether giving nitric oxide gas during and after surgery could lower the risk of acute kidney injury in people undergoing emergency repair of a torn aorta. 106 adults were randomly assigned to receive nitric oxide or a placebo. The main goal was to see how many developed kidney problems within 48 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nitric oxide gas
What this could lead to
If it works, this could offer a simple way to protect kidney function during high-risk heart surgery.
What could go wrong
This is a small, single-center trial. The results may not apply to all patients, and nitric oxide can have side effects like methemoglobinemia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

106 people

The number who actually took part.

Started

Nov 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Provide written informed consent; 2. Participants must be over 18 years of age; 3. Participants should meet the diagnostic and treatment guidelines for thoracic aortic diseases jointly issued by ACC/AHA in 2022, have received clinical and radiological diagnosis of acute type A aortic dissection, and undergone surgical thoracotomy within two weeks after symptom onset. Exclusion Criteria: 1. Missing baseline value or missing postoperative serum creatinine value (Scr); 2. Preoperative eGFR less than 30ml/min/1.73m2 or receive renal replacement therapy; 3. History of kidney disease, including glomerular diseases: acute glomerulonephritis, rapidly progressive glomerulonephritis, chronic glomerulonephritis, nephrotic syndrome, etc., secondary nephropathy: lupus nephritis, diabetic nephropathy, interstitial nephritis, renal tubular disease, chronic renal failure, renal replacement therapy, etc.; 4. Previous renal tumor, kidney transplantation, and other related surgery; 5. Patients with single kidney; 6. History of malignant tumor or received radiotherapy and chemotherapy; 7. Severe skeletal muscle disease and autoimmune disease; 8. Preoperative dissection rupture or hemodynamic instability (systolic blood pressure \<90mmHg); 9. Life expectancy less than 90 days; 10. Pregnant and lactating women, patients with mental disorders; 11. With intravascular or extravascular hemolytic disease; 12. Have participated in other clinical trials.

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Conditions

The condition(s) this trial relates to.

Aortic Dissection acute kidney injury prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury Acute type A aortic dissection Nitrous oxide

Contacts and locations

Locations

  • Beijing Anzhen Hospital

    Beijing, Beijing Municipality, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.