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New Light-Based imaging could spot Limb-Threatening compartment syndrome early

NCT ID NCT05672381

Diagnosis Sponsor: Dartmouth-Hitchcock Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a special camera that uses near-infrared light and a dye can help doctors diagnose acute compartment syndrome—a dangerous condition where pressure builds up in muscles after a severe injury. Researchers observed 15 adults with suspected compartment syndrome and used the imaging to measure blood flow and oxygen in the muscle. The goal was to see if this non-invasive method could identify which patients truly have the condition, potentially avoiding unnecessary surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this imaging method could help doctors diagnose acute compartment syndrome faster and more accurately, potentially reducing the need for emergency surgery.
What could go wrong
This is a very small pilot study with only 15 participants, so results may not apply to everyone. The imaging technique is still experimental and not yet proven to be reliable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

15 people

The number who actually took part.

Started

May 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects receiving care at DHMC (Lebanon) with high energy lower leg or forearm trauma at risk for Acute Compartment Syndrome.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Clinical suspicion of acute compartment syndrome based on orthopaedic provider assessment. Clinical suspicion would be based upon the presence of one or more of these findings: * Pain out of proportion to visible findings * Escalating doses of pain medication * Pain with passive stretch of toes and/or fingers * Pallor, paresthesias, pulselessness * Tense soft tissues * High energy tibia or forearm fracture * Provision of informed consent Exclusion Criteria: * History of allergy to ICG and/or iodine * Pregnant women or nursing mothers * Any patient with an open wound for whom NIRST device cannot be applied \>4cm from the open wound will be excluded from NIRST imaging.

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Conditions

The condition(s) this trial relates to.

compartment syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Compartment syndrome of forearm Compartment syndrome of lower leg Compartment syndromes

Contacts and locations

Locations

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, 03766, United States