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Could niacin help stop migraines? new trial tests the vitamin

NCT ID NCT05846373

Symptom relief Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding niacin (a B vitamin) to a standard beta blocker could help prevent migraines. 58 adults with moderate to severe migraines took either 500 mg, 1000 mg of niacin, or a placebo daily for 12 weeks. Researchers measured changes in migraine days and pain severity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Niacin (nicotinic acid) extended-release tablets
What this could lead to
If it works, adding niacin to a beta blocker could reduce the number of migraine days for people with moderate to severe migraines.
What could go wrong
This is a small, early-phase trial with only 58 participants. Niacin may cause side effects like flushing, and the results may not apply to everyone with migraines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

58 people

The number who actually took part.

Started

Nov 2022

Finished

Jan 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients suffering from migraine with or without aura according to International ICHD 3 criteria 2. Patients with 4-15 qualified migraine attacks per month during the four weeks of the Baseline Phase 3. History of headache for at least 1 year 4. Age at onset of migraine should be less than 50 years 5. Headache intensity: Moderate to severe (Visual analogue scale score at least 3) 6. Consuming one β Blocker as prophylaxis Exclusion Criteria: 1. Pregnancy and lactation 2. Known case of any hepatic, psychiatric diseases except depression, diabetes mellitus (DM), gout, peptic ulcer disease 3. Known hypersensitivity to niacin 4. Consumption of certain drugs Lipid lowering agents Antiplatelet and Anticoagulants Antihypertensive medications Alcohol or other abusive drugs 5. Plasma Nicotinic acid level \> 8.45 µg/mL

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Migraine prophylaxis

Contacts and locations

Locations

  • BSMMU

    Dhaka, 1000, Bangladesh

More trials for these conditions

Other studies related to the condition(s) this trial covers.