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Brain scans reveal how language therapy rewires Kids' brains

NCT ID NCT05268341

Knowledge-focused Sponsor: University of Cincinnati Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses brain imaging to understand how a computer-based grammar program affects brain connections in preschoolers with Developmental Language Disorder (DLD). Researchers will scan children's brains before and after therapy to see changes in memory and language networks. The goal is to learn how the brain supports grammar learning, which could lead to better, more personalized treatments for DLD.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
My Sentence Builder (computer-assisted treatment program for expressive grammar)
What this could lead to
If successful, this could reveal how the brain changes with grammar therapy, helping design more personalized treatments for children with language disorders.
What could go wrong
This is an early-stage observational study with no treatment outcome data yet. The brain changes seen may not translate to better language skills, and results may not apply to all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2022

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

48 to 71 months

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ages 48-71 months * average nonverbal intelligence quotient (IQ) * enrolled in participating center * typically developing (receptive and expressive language, social, articulation, other) * DLD for expressive grammar * typical oral motor function * typical social/pragmatics skills * average hearing thresholds * monolingual and native Standard English speakers * does not have any uncorrected vision challenges Exclusion Criteria: * receiving co-occurring speech-language or other intervention for communication * not MRI safe * special education placement of child based on ability or behavior

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Conditions

The condition(s) this trial relates to.

familial developmental dysphasia Language Development Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Developmental language disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CWFF CHild Development Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

  • Cincinnati Children's Hospital

    NOT_YET_RECRUITING

    Cincinnati, Ohio, 45229, United States

  • Empower Learn Create INC

    RECRUITING

    Cincinnati, Ohio, 45220, United States

  • New Horizon Childcare

    NOT_YET_RECRUITING

    Cincinati, Ohio, 45207, United States

  • University of Cincinnati

    RECRUITING

    Cincinnati, Ohio, 45267, United States

  • Wesley Education Center for Children and Families

    RECRUITING

    Cincinnati, Ohio, 45229, United States

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