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Can a skin scaffold boost nerve repair in fingertip injuries?

NCT ID NCT07292415

Symptom relief Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether wrapping a stitched finger nerve with MatriDerm, a collagen-elastin matrix normally used for skin healing, improves sensation recovery. Seventy people with traumatic finger nerve cuts will be randomly assigned to receive either standard nerve stitching alone or stitching plus MatriDerm wrapping. Researchers will measure fingertip touch sensitivity one year after surgery to see if the wrap helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MatriDerm (collagen-elastin matrix)
What this could lead to
If it works, this could provide a simple way to improve sensation recovery after finger nerve injuries and reduce complications like neuromas.
What could go wrong
This is an early-stage study with only 70 participants, so results may not apply broadly. The improvement over standard stitching may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient aged 16 to 75 2. Patient with a palm or finger wound with sensory nerve damage (partial \>50% or total) 3. Indication for repair by direct suture in the operating room 4. Possibility of attending a follow-up visit after 1 year 5. Patient affiliated with a social security system 6. Patient who has given their written consent after receiving written and oral information Exclusion Criteria: 1. Pre-existing sensory disorders 2. History of nerve damage in the affected hand 3. Known hypersensitivity to bovine proteins 4. Active infection in the affected hand 5. Patient protected by law under guardianship or curatorship, or unable to participate in a clinical study MATRINERVE 24-PP-12 Version No. 1.0 dated July 22, 2025 Page 8 of 40 clinical trial under Article L. 1121-16 of the French Public Health Code 6. Pregnant or breastfeeding women of childbearing age

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Conditions

The condition(s) this trial relates to.

traumatic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

This study is testing the use of matriderm

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU de Nice

    RECRUITING

    Nice, Alpes Maritimes, 06000, France