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Could zapping nerves or muscles help you breathe better at night?

NCT ID NCT06627127

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether stimulating certain nerves or muscles in the throat can improve breathing in people with obstructive sleep apnea. Researchers placed temporary electrodes and measured airflow during sleep in 35 adults. The goal was to see if this approach is feasible and could reduce apnea events.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
electrical stimulation device
What this could lead to
If successful, this could point toward a new treatment option for obstructive sleep apnea that uses targeted nerve or muscle stimulation.
What could go wrong
This is a small, early proof-of-concept study with only 35 participants. It focuses on feasibility and short-term effects, so results may not lead to a widely available treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

35 people

The number who actually took part.

Started

Nov 2023

Finished

Jan 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: A subject must meet all of the following inclusion criteria to be eligible for inclusion in this study: * Age above 18 years not under guardianship, under curatorship or under judicial protection. * Body Mass Index (BMI) \< 35 kg/m2. * OSA (15 \< AHI \< 80 events/h sleep) documented by a sleep study performed during the past 24 months in the absence of any major weight change or other medical issues. * Subject must be eligible for a diagnostic DISE or surgical procedure (acute study measures only). * Written informed consent obtained from the subject prior to performing any study specific procedure. * Willing and capable to comply with all study requirements, including specific lifestyle considerations, evaluation procedures and questionnaires for the whole duration of the trial. Exclusion Criteria: Subjects meeting any of the following criteria will be excluded from participation in this study: * Major anatomical or functional abnormalities that would impair the ability of the electrode arrays to be positioned. * Significant comorbidities that contraindicate surgery or general anesthesia/DISE * Significant tongue weakness * Any other chronic medical illness or condition that contraindicates a surgical procedure or general anesthesia/DISE in the judgment of the investigator. * Prior surgery or treatments that could compromise the placement and effectiveness of the electrode array systems: * Airway cancer surgery or radiation, * Mandible or maxilla surgery in the previous 3 years (not counting dental treatments), * Other upper airway surgery to remove obstructions related to OSA in the previous 3 months (e.g., uvulopalatopharyngoplasty (UPPP), tonsillectomy, nasal airway surgery), * Prior hypoglossal nerve stimulation device implantation. * Currently pregnant, or breastfeeding during the study period

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Adelaide Institute for Sleep Health, Flinders University

    Adelaide, South Australia, 5042, Australia

  • Complete ENT

    Brisbane, Queensland, 4000, Australia

  • Illawara ENT

    Wollongong, New South Wales, 2500, Australia

  • Perth Head and Neck Surgery

    Perth, Western Australia, 6009, Australia

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