Nerve block showdown: which injection cuts opioid need after breast surgery?
NCT ID NCT06833697
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study compared two types of nerve blocks—erector spinae plane block and serratus posterior superior intercostal plane block—for pain relief after breast and armpit surgery. The goal was to see which block reduces the need for opioid painkillers and their side effects like nausea and breathing problems. Sixty adults aged 18-80 who had breast surgery with lymph node removal took part. Both blocks were given after surgery but before waking up, using ultrasound guidance.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nerve block (erector spinae plane block or serratus posterior superior intercostal plane block)
- What this could lead to
- If one block works better, it could help patients use fewer opioids after breast surgery, reducing side effects like nausea and breathing trouble.
- What could go wrong
- This is a small, completed study (60 people) comparing two similar techniques. The results may not apply to all patients or surgeries, and neither block may prove clearly better.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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60 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Sep 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * aged 18-80 years * Classified as ASA (American Society of Anesthesiologists) physical status I-III * Scheduled for breast surgery with axillary lymph node dissection Exclusion Criteria: * Patients with a history of allergies * allergic to local anesthetics * pregnant women * psychiatric or neurological disorders
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Medipol University
Istanbul, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could lying a certain way after a nerve block double its pain relief?
- Can a targeted nerve block cut opioid use after spine surgery?