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New nerve block may cut opioid use after knee surgery

NCT ID NCT05980546

Symptom relief Sponsor: Hospital for Special Surgery, New York Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding a specific nerve block (genicular and anterior femoral cutaneous nerve block) to standard care can lower pain and the need for strong painkillers after total knee replacement. 244 adults having knee replacement surgery took part. Half received the extra nerve block, half did not. The goal was to see if the nerve block group used fewer opioids and had less pain in the first 24 hours after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

244 people

The number who actually took part.

Started

Jun 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients age 18-80 * patients undergoing ambulatory unilateral total knee arthroplasty, including 23 hour stay cohort * ASA I-III * BMI \< 35 Exclusion Criteria: * history of chronic pain syndromes * chronic opioid use (daily morphine milligram equivalents \> 30 mg for at least 3 months) * contraindication to peripheral nerve blocks * contraindication to neuraxial anesthesia * history of peripheral neuropathy or pre-existing neurological deficits * Psychiatrics or cognitive disorder that prohibit patient from following study protocol * allergy to local anesthetic or study medications * multiligament surgery * history of substance abuse * infection at the site of injection * chronic kidney disease * currently taking anticonvulsants

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Conditions

The condition(s) this trial relates to.

opioid abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Genicular nerve block Opioid use Total knee replacement

Contacts and locations

Locations

  • Hospital for Special Surgery

    New York, New York, 10021, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.