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Can a targeted nerve block cut opioid use in High-Risk C-Sections?

NCT ID NCT07748741

Symptom relief Sponsor: Kasr El Aini Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether an ultrasound-guided erector spinae plane block can reduce pain and the need for opioids during and after cesarean sections in women with placenta accreta, a condition where the placenta grows too deeply into the uterine wall. Participants will receive the nerve block or standard care under general anesthesia, and researchers will measure total opioid use and pain scores over 24 hours. The goal is to see if this nerve block can improve pain control while reducing opioid exposure for both mother and baby.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ultrasound-guided erector spinae plane block (a nerve block procedure)
What this could lead to
If effective, this nerve block could reduce the need for opioids during and after C-sections for placenta accreta, potentially lowering risks for both mother and baby.
What could go wrong
This is a small, early-stage trial, and the nerve block may not provide adequate pain relief in all cases. There are also risks of complications from the procedure itself, such as bleeding or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

70 people

The number who actually took part.

Started

Jan 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists physical status II. * Female patients aged 18 to 40 years' old. * BMI less than 40. * Diagnosed placenta accreta Exclusion Criteria: * • Patient's unwillingness to participate in the study. * Contraindication to receive regional anesthesia. * Patients with anticipated difficult airway. * Allergy to any of the drugs used in the study * Any apparent deformity in the spine. * Hemodynamic instability. * Fetal distress. * Surgically complicated cases.

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Conditions

The condition(s) this trial relates to.

placenta accreta

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

C-section ESPB General anesthesia Placenta accreta

Contacts and locations

Locations

  • Kasr Al Aini Hospitals

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.