Can zapping knee nerves first make artery embolization work better?
NCT ID NCT06514755
First seen Sep 23, 2026 · Last updated Sep 23, 2026
Summary
Researchers are testing whether performing genicular nerve ablation before geniculate artery embolization improves pain relief and knee function in adults with chronic knee pain from osteoarthritis. The trial compares two groups: one receives the sequential procedures, the other receives artery embolization alone. Participants will have their pain and function measured over six months to see if the combined approach offers more benefit.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- genicular nerve ablation followed by geniculate artery embolization
- What this could lead to
- If the sequential approach works, it could offer better pain relief and knee function for people with chronic knee pain from osteoarthritis who have not improved with conservative care.
- What could go wrong
- This is a small trial of 38 people at a single center, so results may not apply broadly. Both procedures carry risks such as infection, bleeding, or nerve damage, and the added nerve ablation may not provide extra benefit over artery embolization alone.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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38 people
The number who actually took part.
- Started
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Sep 2024
- Finished
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Aug 2025
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18 to 80 years. * Diagnosed with chronic knee pain refractory to conservative treatment. * Able to provide informed consent. * Agree to follow the study procedures and attend follow-up visits. Exclusion Criteria: * Contraindications to GNA or GAE procedures (e.g., allergy to local anesthetics, active infection at the procedure site). * Recent knee surgery within the last six months. * Severe comorbid conditions that may interfere with the study outcomes (e.g., rheumatoid arthritis, other severe autoimmune diseases). * Current participation in another clinical trial that could interfere with the outcomes of this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zagazig University, Faculty of Medicine
Zagazig, 44519, Egypt
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Other studies related to the condition(s) this trial covers.
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