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ICU dialysis study seeks sweet spot for fluid removal

NCT ID NCT06071026

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 39 intensive care patients with acute kidney failure who needed dialysis to remove excess fluid. Researchers tested three different fluid removal rates (1, 2, and 3 ml per kg per hour) to see which caused the fewest drops in blood pressure while still effectively removing fluid. The goal was to find the safest rate to prevent dangerous instability during treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

39 people

The number who actually took part.

Started

Oct 2023

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients hospitalised in the intensive care unit of one of the two participating centres * Patients with Kidney Disease: Improving Global Outcomes 3 (KDIGO3) acute kidney injury (AKI) requiring a continuous RRT during their stay in the intensive care unit, regardless of the aetiology of the AKI * Need to prescribe water loss by net ultrafiltration (NUF), defined by at least one of the following sub-criteria: 1. weight gain ≥ 1 kg relative to entry weight 2. oligo-anuria ≥ 24 hours 3. clinical impact of fluid overload as judged by the clinician: acute lung oedema clinical or at CT-scan, difficulty of weaning from mechanical ventilation. * Hemodynamic stability in the 2 hours preceding the start of NUF, defined by all of the following sub-criteria: 1. absence of vasopressors (noradrenaline) or stability or reduction in their dosage 2. no need for resuscitative fluids as judged by the clinician * Patient or his/her trusted support person/legal representative/family member having given free and informed consent, and having signed the consent form or patient included in an emergency situation. * Patient affiliated to or benefiting from a health insurance scheme. Exclusion Criteria: * Patient moribund, with life expectancy too low to benefit from treatment, or with decision to discontinue treatment * Patient participating in an another interventional study * Patient in exclusion period determined by another study * Patient under court protection or guardianship * Patient/trusted person/legal representative/family member for whom it is impossible to give informed information. * Pregnant, parturient or breast-feeding patient.

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Conditions

The condition(s) this trial relates to.

acute kidney injury Edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fluid overload Hemodynamic instability

Contacts and locations

Locations

  • Centre Hospitalier Universitaire de Nîmes

    Nîmes, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.