Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Could a common heart drug stop diabetes-related heart failure?

NCT ID NCT03744975

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether the drug Entresto (LCZ 696) can improve how the kidneys and heart handle extra salt and fluid in people with type 2 diabetes. Some participants had early signs of heart stiffness (diastolic dysfunction) and others did not. The goal was to see if the drug could prevent progression to full-blown heart failure. The study involved 72 adults and measured changes in blood and urine markers after a saline infusion.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Entresto (LCZ 696, a neprilysin inhibitor)
What this could lead to
If successful, this could point toward a way to prevent heart failure in people with type 2 diabetes who have early signs of heart stiffness.
What could go wrong
This is a small, early-phase study (72 participants) that measures short-term body responses, not long-term outcomes. The drug may not prevent heart failure in real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

72 people

The number who actually took part.

Started

May 2018

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Type 2 diabetes mellitus * On at least one oral hypoglycemic agent, or glucagon-like peptide analogue or insulin, for at least 6 months * EF \> 50% without diastolic dysfunction or EF \> 50% with grade 2 or more diastolic dysfunction, without prior diagnosis, or signs and symptoms, of heart failure * Minimal distance of \>450 meters on a 6-minute walk. If the subject is not able to walk 450 meters due to pain in hips and/or knees, and not fatigue or shortness of breath, then they will still qualify for the protocol. Exclusion Criteria * HbA1C\> 9 % at enrollment * prior diagnosis, or signs and symptoms, of heart failure; * Currently taking a loop diuretic * myocardial infarction within 6 months of Visit 2 * unstable angina within 6 months of Visit 2 * significant (\> moderate) valvular stenosis, hypertrophic, restrictive or obstructive cardiomyopathy, constrictive pericarditis, primary pulmonary hypertension, or biopsy proven active myocarditis * severe congenital heart diseases * sustained ventricular tachycardia or ventricular fibrillation within 14 days of screening * second or third degree heart block without a permanent cardiac pacemaker * stroke within 3 months of screening, or other evidence of significantly compromised CNS perfusion * ALT \>2 times the upper limit of normal * serum sodium of \< 125 mEq/dL or \> 160 mEq/dL * serum potassium of \< 3.5 mEq/dL or \> 5.9 mEq/dL * hemoglobin \< 9 gm/dl * eGFR \< 30 ml/min (at screening) * other acute or chronic medical conditions or laboratory abnormality which may increase the risks associated with study participation or may interfere with interpretation of the data * received an investigational drug within 1 month prior to dosing; * patients with an allergy to iodine * female subject who is pregnant or breastfeeding * in the opinion of the investigator, is unlikely to comply with the study protocol or is unsuitable for any reason

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Diabetes mellitus type 2 are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.