New combo therapy aims to boost survival in returning head and neck cancer
NCT ID NCT07195734
First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 33 times
Summary
This study tests whether adding chemotherapy or a chemo-immunotherapy combination before standard salvage surgery helps people with a specific type of head and neck cancer that has come back or persisted. About 180 adults with PD-L1 positive cancer will be randomly assigned to one of three approaches. The goal is to see if these added treatments improve how long patients live without the cancer returning.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Broadlawns Medical Center
RECRUITINGDes Moines, Iowa, 50314, United States
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Clackamas Radiation Oncology Center
RECRUITINGClackamas, Oregon, 97015, United States
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Drexel Town Square Health Center
RECRUITINGOak Creek, Wisconsin, 53154, United States
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Emory Proton Therapy Center
RECRUITINGAtlanta, Georgia, 30308, United States
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Emory University Hospital Midtown
RECRUITINGAtlanta, Georgia, 30308, United States
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Froedtert Menomonee Falls Hospital
RECRUITINGMenomonee Falls, Wisconsin, 53051, United States
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Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITINGWest Bend, Wisconsin, 53095, United States
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Froedtert and MCW Moorland Reserve Health Center
RECRUITINGNew Berlin, Wisconsin, 53151, United States
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Iowa Methodist Medical Center
RECRUITINGDes Moines, Iowa, 50309, United States
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LSU Health Baton Rouge-North Clinic
RECRUITINGBaton Rouge, Louisiana, 70805, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Mercy Medical Center - Des Moines
RECRUITINGDes Moines, Iowa, 50314, United States
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Methodist Jennie Edmundson Hospital
SUSPENDEDCouncil Bluffs, Iowa, 51503, United States
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Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
RECRUITINGOmaha, Nebraska, 68114, United States
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Nebraska Methodist Hospital
RECRUITINGOmaha, Nebraska, 68114, United States
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Our Lady of the Lake Physician Group
RECRUITINGBaton Rouge, Louisiana, 70808, United States
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Providence Newberg Medical Center
RECRUITINGNewberg, Oregon, 97132, United States
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Providence Portland Medical Center
RECRUITINGPortland, Oregon, 97213, United States
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Providence Saint Vincent Medical Center
RECRUITINGPortland, Oregon, 97225, United States
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Providence Willamette Falls Medical Center
RECRUITINGOregon City, Oregon, 97045, United States
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Rush MD Anderson Cancer Center
RECRUITINGChicago, Illinois, 60612, United States
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Sutter Medical Center Sacramento
RECRUITINGSacramento, California, 95816, United States
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Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITINGAnkeny, Iowa, 50023, United States
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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITINGDes Moines, Iowa, 50309, United States
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UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITINGDes Moines, Iowa, 50314, United States
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UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITINGWaukee, Iowa, 50263, United States
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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITINGClive, Iowa, 50325, United States
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USC / Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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University of Kansas Cancer Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Kansas Cancer Center - Briarcliff
RECRUITINGKansas City, Missouri, 64116, United States
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University of Kansas Cancer Center - Lee's Summit
RECRUITINGLee's Summit, Missouri, 64064, United States
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University of Kansas Cancer Center - North
RECRUITINGKansas City, Missouri, 64154, United States
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University of Kansas Cancer Center-Overland Park
RECRUITINGOverland Park, Kansas, 66210, United States
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University of Kansas Hospital-Westwood Cancer Center
RECRUITINGWestwood, Kansas, 66205, United States
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University of Michigan - Brighton Center for Specialty Care
RECRUITINGBrighton, Michigan, 48116, United States
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University of Michigan Rogel Cancer Center
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITINGMadison, Wisconsin, 53718, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITINGMadison, Wisconsin, 53792, United States
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Conditions
Explore the condition pages connected to this study.