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Neem vs. steroid: can a natural gel tame oral lichen planus?

NCT ID NCT07141446

Disease control Sponsor: Goa Dental College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether a neem gel can treat oral lichen planus, a chronic inflammatory mouth condition, as well as a standard steroid paste. Sixty adults used either neem or triamcinolone acetonide twice daily for three months. Researchers measured pain, lesion severity, and anxiety to see if neem is a viable alternative.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Neem gel (1.5%) and triamcinolone acetonide (0.1%)
What this could lead to
If neem works as well as the steroid, it could offer a natural, safer option for managing oral lichen planus symptoms.
What could go wrong
This is a small, early-phase trial with only 60 participants. Neem may not be as effective as the standard treatment, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

60 people

The number who actually took part.

Started

Feb 2023

Finished

Feb 2024

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with clinical \& histopathological diagnosis of OLP. * Patient above 20 years of age. * Patient willing to participate in the study with informed consent. * Patient with recalcitrant OLP. Exclusion Criteria: * Patient with known allergic reaction to Triamcinolone Acetonide or Neem. * Patients with lichenoid lesions. * Patients with associated cutaneous lesions. * Pregnant or lactating females.

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Conditions

The condition(s) this trial relates to.

lichen planus, oral

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral lichen planus

Contacts and locations

Locations

  • Department of Oral Medicine and radiology, Goa Dental College and Hospital, Bambolim Goa India

    Goā, Bambolim, 403202, India

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