New study reveals hidden dangers of severe asthma in kids
NCT ID NCT05632588
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tracked 60 children aged 5 to 15 who survived a near fatal asthma attack in the UK and Ireland. Researchers collected data on risk factors, medical care, and social and environmental influences. The goal is to create better care guidelines and reduce future risks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to better guidelines and care pathways to prevent future near fatal asthma attacks in children.
- What could go wrong
- This is an observational study, not a treatment trial. It describes what happens but does not test any intervention, so it cannot directly improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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60 people
The number who actually took part.
- Started
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Oct 2022
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The number of children and young people identified who experience NFA within the 18-month surveillance period is not known, but is estimated to be c400 (from paediatric intensive care admission data). All UK and ROI hospitals where children may attend with acute asthma could be potential contributing sites. Each case will be followed up for 24 months following the near fatal asthma event.
- Ages
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5 to 15 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * A child/young person is considered to have experienced an episode of near fatal asthma if they meeting any one of the following: 1. Any child aged 5-15 years surviving\* an acute episode of asthma, who when presenting self-ventilating with severe dyspnoea (e.g. inability to speak) and all the following features: 1. Pulse oxygen saturation below 92% despite maximal oxygen therapy (i.e. 10-15l/min oxygen flow via non-rebreather mask) during acute presentation 2. pH \<= 7.2 and/or pCO2 \>=60mmHg or 8kPa 3. Escalation to use of intravenous bronchodilator infusion 2. Any child aged 5-15 years surviving\* an acute episode of asthma, who had a respiratory arrest and/or required cardiopulmonary resuscitation as part of their presentation. 3. Any child age 5-15 years surviving\* an acute episode of asthma for which he/she was invasively ventilated. * surviving to hospital discharge Exclusion Criteria: * CYP not meeting the case definition will be excluded. An expert panel (consisting of three clinicians) will adjudicate borderline cases.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Edinburgh
Edinburgh, United Kingdom