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Can we trust our metabolic tests? a study aims to find out

NCT ID NCT06286761

Knowledge-focused Sponsor: Bettina Mittendorfer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study aims to validate the accuracy and reproducibility of laboratory assays and research techniques used in metabolism research. It will involve up to 100 adults aged 18-75 with a BMI between 18.5 and 45. Participants may undergo various tests, including blood sampling, oral glucose tolerance tests, mixed meal consumption, and imaging like MRI or DEXA, to ensure these methods produce consistent and reliable results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Various laboratory assays and research techniques, including blood tests, endothelial cell collection, oral glucose tolerance test, mixed meal, and imaging (MRI, DEXA, MRS)
What this could lead to
If successful, this could improve the accuracy and reliability of research methods, leading to better understanding and potential treatments for metabolic diseases like obesity and diabetes.
What could go wrong
This is a validation study, not a treatment trial, so it won't directly benefit participants. The results may not apply to all populations or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

convenience population of volunteers in mid-Missouri region

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥18 and ≤75 years of age * body mass index ≥18.5 and ≤45 kg/m2 * Weight stable (i.e., ≤3% change) * ≤150 min of structured exercise/week for at least 2 months before entering the study * Blood glucose: \< 126 mg/dl fasted, \< 200 mg/dl with 2 hour oral glucose tolerance testing * Hemoglobin A1C (HbA1C) ≤6.5% * Dyslipidemia triglycerides ≥125 mg/dL * No chronic kidney disease * Not vegan or vegetarian or on high protein diet (e.g. Atkins) or supplements that are not allowed * No intolerance or allergies to study diet ingredients * No excessive alcohol or tobacco consumption Exclusion Criteria: * \<18 and \>75 years of age * body mass index \<18.5 or \>45 kg/m2 * history of or current significant organ system dysfunction (e.g., heart disease, stroke, diabetes, cancer in remission for \<5 years, dementia, chronic kidney disease) * allergies or intolerances to meal ingredients, vegans or vegetarians * use of medications that could confound the study outcomes (e.g., anti-inflammatories, immune modulators, etc) * take dietary supplements (e.g., certain pre- and pro-biotics, fiber, fish oil supplements) * engaged in regular structured exercise \>150 min per week * alcohol use disorder as defined by the National Institute of Alcohol Abuse and Alcoholism or use of controlled substances * pregnant women * persons who use tobacco * prisoners * the inability to grant voluntary informed consent.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Missouri School of Medicine

    RECRUITING

    Columbia, Missouri, 65212, United States

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