New nasal spray could clear stuffy noses in teens with nasal polyps

NCT ID NCT03747458

Ongoing Symptom relief Sponsor: Optinose US Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 18, 2026 · Updated 25 times

Summary

This study tests a nasal spray called OPN-375 in about 72 teenagers (ages 12-17) who have nasal polyps—growths inside the nose that cause congestion. The spray is given twice a day for 16 weeks, and some participants receive a placebo (inactive spray) for comparison. The goal is to see if the spray reduces stuffiness and shrinks the polyps, followed by a 12-week phase where everyone gets the active spray.

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Contacts and locations

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Locations

Allergy Asthma & Immunology Research Institute

Charlotte, North Carolina, 28204, United States
Allergy and Asthma Consultants

Redwood City, California, 94063, United States
Allergy, Asthma & Clinical Research Center

Oklahoma City, Oklahoma, 73120, United States
Carolina ENT

Orangeburg, South Carolina, 29118, United States
Central California Clinical Research

Fresno, California, 93720, United States
Centro Medico INSARES

Mendoza, M5500CCG, Argentina
Centro de Investigaciones Clinicas - Instituto de la Salud Rosario

Rosario, Santa Fe Province, S200DBS, Argentina
Chicago ENT

Chicago, Illinois, 60657, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30322, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital of Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Clinica Mayo, UMCB

San Miguel de Tucumán, Tucumán Province, T4000IHE, Argentina
Eastern Virginia Medical School - Otolaryngology

Norfolk, Virginia, 23507, United States
Fundacion CIDEA

Buenos Aires, C1411ABE, Argentina
InAER - Investigaciones en Alergia y Enfermedades Respiratorias

Buenos Aires, C1425BEN, Argentina
Instituto Medico Rio Cuarto

Río Cuarto, Córdoba Province, X5008AEV, Argentina
Instituto Medico de la Fundacion de Estudios Clinicos - Consultorios Integrados Rosario

Rosario, Santa Fe Province, S2000DEJ, Argentina
Instituto de Asma Alergia y Enfermedades Respiratoria (IAAER)

Corrientes, W3400AVV, Argentina
Kentuckiana ENT

Louisville, Kentucky, 40205, United States
Kern Research

Bakersfield, California, 93301, United States
Rady Children's Hospital San Diego

San Diego, California, 92123, United States
STAAMP Research

San Antonio, Texas, 78229, United States
Sacramento ENT

Roseville, California, 95661, United States
San Tan Allergy & Asthma

Gilbert, Arizona, 85234, United States
Sanatorio Guemes

Buenos Aires, C1180AAX, Argentina
Sensa Health

Los Angeles, California, 90006, United States
Spokane ENT

Spokane Valley, Washington, 99216, United States
University of Rochester

Rochester, New York, 14642, United States
University of Utah

Salt Lake City, Utah, 84132, United States
Vital Prospects Clinical Research Institute, P.C.

Tulsa, Oklahoma, 74136, United States

Conditions

Explore the condition pages connected to this study.

BILATERAL NASAL POLYPOSIS