Can a nose moisturizer make oxygen therapy easier to tolerate?
NCT ID NCT07822451
First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time
Summary
Oxygen delivered through a nasal cannula can dry out and irritate the nose. Researchers are testing whether adding saline nasal drops or a hyaluronic acid nasal spray reduces that dryness in adults receiving low-flow oxygen in a coronary intensive care unit. The trial assigns 150 participants to oxygen alone, oxygen plus saline drops, or oxygen plus the hyaluronic acid spray, and compares nasal dryness, comfort, and pain over 12 hours.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 0.9% isotonic saline nasal drops or a hyaluronic acid-based nasal spray
- What this could lead to
- If either moisturizer helps, hospitals could add a simple, low-cost step to oxygen therapy that keeps patients more comfortable during treatment.
- What could go wrong
- Nasal dryness often improves on its own, and a 12-hour study cannot show whether any benefit lasts. The results may not apply to people with nasal conditions excluded from the trial.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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150 people
The number who actually took part.
- Started
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Jul 2026
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18 years or older * Admission to the coronary intensive care unit * Receiving low-flow oxygen therapy via a standard nasal cannula * Expected to require oxygen therapy for at least 12 hours Exclusion Criteria: * Severe nasal septal deviation * Nasal polyps * Recent nasal surgery or trauma * Acute upper respiratory tract infection * Allergic rhinitis * Known hypersensitivity to isotonic saline or hyaluronic acid preparations
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sultan Abdulhamid Han Training and Research Hospital
Istanbul, Istanbul, 34674, Turkey (Türkiye)