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Can a nose moisturizer make oxygen therapy easier to tolerate?

NCT ID NCT07822451

Symptom relief Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Oxygen delivered through a nasal cannula can dry out and irritate the nose. Researchers are testing whether adding saline nasal drops or a hyaluronic acid nasal spray reduces that dryness in adults receiving low-flow oxygen in a coronary intensive care unit. The trial assigns 150 participants to oxygen alone, oxygen plus saline drops, or oxygen plus the hyaluronic acid spray, and compares nasal dryness, comfort, and pain over 12 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
0.9% isotonic saline nasal drops or a hyaluronic acid-based nasal spray
What this could lead to
If either moisturizer helps, hospitals could add a simple, low-cost step to oxygen therapy that keeps patients more comfortable during treatment.
What could go wrong
Nasal dryness often improves on its own, and a 12-hour study cannot show whether any benefit lasts. The results may not apply to people with nasal conditions excluded from the trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

150 people

The number who actually took part.

Started

Jul 2026

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older * Admission to the coronary intensive care unit * Receiving low-flow oxygen therapy via a standard nasal cannula * Expected to require oxygen therapy for at least 12 hours Exclusion Criteria: * Severe nasal septal deviation * Nasal polyps * Recent nasal surgery or trauma * Acute upper respiratory tract infection * Allergic rhinitis * Known hypersensitivity to isotonic saline or hyaluronic acid preparations

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nasal dryness associated with low-flow oxygen therapy

Contacts and locations

Locations

  • Sultan Abdulhamid Han Training and Research Hospital

    Istanbul, Istanbul, 34674, Turkey (Türkiye)