Which blade threads the needle? trial pits two videolaryngoscope designs for nasal intubation
NCT ID NCT07822308
First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time
Summary
Researchers compare two C-MAC videolaryngoscope blade designs for placing a breathing tube through the nose in adults having surgery under general anesthesia. Participants are randomly assigned to intubation with either a hyperangulated D-BLADE or a Macintosh-style blade. The study measures how often extra airway maneuvers are needed, how many attempts it takes, total time to successful intubation, and any airway or anesthesia-related adverse events. The goal is to see which blade design works better and more safely for this procedure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- C-MAC videolaryngoscope with either a D-BLADE or a Macintosh blade
- What this could lead to
- If one blade design proves faster or more reliable, anesthesiologists could adopt it as a standard tool for nasal intubation, potentially reducing airway trauma and procedure time.
- What could go wrong
- This is a single-center study of 220 adults with normal nasal anatomy, so results may not apply to emergency cases, patients with abnormal airways, or children. Both blades are already in clinical use, and differences may be small.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 220 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1\. Patients 18 years old or above Exclusion Criteria: 1. Patients requiring awake fiber optic intubation 2. Emergency cases 3. High risk of aspiration 4. Bleeding diathesis 5. Abnormal nasal anatomy 6. Chronic Epistaxis 7. Severe cardiorespiratory disease 8. Basilar skull fracture
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Mount Sinai Hospital
Toronto, Ontario, M5G 1X5, Canada