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Which blade threads the needle? trial pits two videolaryngoscope designs for nasal intubation

NCT ID NCT07822308

Symptom relief Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers compare two C-MAC videolaryngoscope blade designs for placing a breathing tube through the nose in adults having surgery under general anesthesia. Participants are randomly assigned to intubation with either a hyperangulated D-BLADE or a Macintosh-style blade. The study measures how often extra airway maneuvers are needed, how many attempts it takes, total time to successful intubation, and any airway or anesthesia-related adverse events. The goal is to see which blade design works better and more safely for this procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
C-MAC videolaryngoscope with either a D-BLADE or a Macintosh blade
What this could lead to
If one blade design proves faster or more reliable, anesthesiologists could adopt it as a standard tool for nasal intubation, potentially reducing airway trauma and procedure time.
What could go wrong
This is a single-center study of 220 adults with normal nasal anatomy, so results may not apply to emergency cases, patients with abnormal airways, or children. Both blades are already in clinical use, and differences may be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 220 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1\. Patients 18 years old or above Exclusion Criteria: 1. Patients requiring awake fiber optic intubation 2. Emergency cases 3. High risk of aspiration 4. Bleeding diathesis 5. Abnormal nasal anatomy 6. Chronic Epistaxis 7. Severe cardiorespiratory disease 8. Basilar skull fracture

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nasal intubation

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Mount Sinai Hospital

    Toronto, Ontario, M5G 1X5, Canada