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Tiny holes in bone may help knee cartilage heal

NCT ID NCT05660161

Symptom relief Sponsor: Ente Ospedaliero Cantonale, Bellinzona Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Knee cartilage has limited healing ability, and damage can lead to early arthritis. This pilot study tests nanofracture surgery, which makes small, deep holes in the bone under the cartilage to release healing marrow cells. Researchers will follow 20 adults aged 16 to 50 who have knee cartilage lesions and are scheduled for surgery. They will measure knee function with a patient questionnaire and check cartilage healing using MRI.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nanofracture surgery, a procedure that makes tiny deep holes in the bone beneath knee cartilage to draw in healing marrow cells
What this could lead to
If nanofracture works, it could offer a less damaging way to repair knee cartilage and possibly delay early arthritis. It may also become an alternative to standard microfracture surgery.
What could go wrong
This is a small pilot study with 20 people, so results may not hold in larger groups. Surgery carries risks like infection, stiffness, or poor cartilage regrowth, and some patients may need further treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with cartilage lesions of the knee scheduled for surgery * Age 16-50 * BMI between 18.5 and 30 points * Ability to give informed consent Exclusion Criteria: * Uncorrected knee instability * Meniscectomy \> 50% * Uncorrected knee misalignment * Uncontrolled metabolic diseases * Inability to give informed consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cartilage damage

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • EOC

    RECRUITING

    Lugano, 6900, Switzerland

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