New combo tackles meth cravings on demand
NCT ID NCT04791969
First seen Oct 31, 2025 · Last updated Jun 21, 2026 · Updated 28 times
Summary
This study tested whether taking naltrexone pills only when needed, combined with a smartphone app that offers real-time support, can help men who have sex with men reduce methamphetamine use. Sixty participants were randomly assigned to receive either the drug or a placebo, plus the app, for 12 weeks. The goal was to see if the approach could lower meth-positive urine tests and improve HIV prevention behaviors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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San Francisco Department of Public Health
San Francisco, California, 94102, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
naltrexone (a drug that blocks opioid receptors, used here to reduce meth cravings)
What this could lead to
If it works, this could offer a practical, on-demand treatment to help men who have sex with men cut down meth use and lower their risk of HIV.
What could go wrong
This is a small, early-phase trial with only 60 participants, so results may not apply to everyone. The drug is taken only as needed, which may not work for all users.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.