New hope for faster, safer waking after surgery

NCT ID NCT04713358

Completed Symptom relief Sponsor: RenJi Hospital Source: ClinicalTrials.gov ↗

First seen Feb 27, 2026 · Last updated May 18, 2026 · Updated 15 times

Summary

This study tested whether nalmefene, a drug that blocks opioids, can help patients wake up more quickly and safely after general anesthesia. Over 500 adults undergoing elective surgery received nalmefene or a placebo, and researchers measured how long they stayed in the recovery room. The goal is to improve the quality of post-anesthesia recovery and reduce complications like slow breathing or confusion.

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Contacts and locations

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Locations

Renji Hospital

Shanghai, Shanghai Municipality, 200127, China
Shanghai Tong Ren Hospital

Shanghai, Shanghai Municipality, 200000, China
The First Affiliated Hospital of Guangxi Medical University

Guangxi, Guangxi, 530000, China
The First Affiliated Hospital of Zhengzhou University

Henan, Zhengzhou, 450000, China

Conditions

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RESUSCITATION