Can common supplements prevent serious gut damage after poisoning?
NCT ID NCT07229456
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether N-acetyl cysteine (NAC) and vitamin D, given alongside standard care, can reduce the risk of esophageal or stomach strictures (scarring that narrows the passage) in children who have swallowed a corrosive substance. Eighty children aged 0–18 with moderate to severe symptoms are randomly assigned to one of four groups: standard care alone, standard care plus NAC, standard care plus a high-dose vitamin D injection, or standard care plus both NAC and vitamin D. The main goal is to see if these supplements lower the rate of stricture formation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- N-acetyl cysteine and vitamin D
- What this could lead to
- If it works, this could offer a simple, safe way to prevent serious scarring in the esophagus or stomach after swallowing a corrosive substance.
- What could go wrong
- This is a small, single-center trial with only 80 children. The results may not apply to everyone, and the supplements might not reduce stricture risk as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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80 people
The number who actually took part.
- Started
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Oct 2024
- Expected to finish
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Dec 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Up to 18 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * The study included all patients aged from 0 to 18 years old, of both sex, admitted to the PCC-ASUH with confirmed history of corrosive ingestion and exhibiting moderate or severe symptoms (as determined by Poisoning Severity Score 2 or 3, respectively) and DROOL score (Drooling, Reluctance, Oropharynx, Others, and leukocytosis) ≤ 6 Exclusion Criteria: * o Asymptomatic patients. * Patients exposed to corrosives through routes other than ingestion (e.g., inhalation, dermal or eye contact). * Patients with a delay time of more than 24 h. * Patients who co-ingested other poisons. * Patients presented with GIT perforation after corrosive ingestion. * Patients who received treatment before admission. * Patients receiving chemotherapy or radiation. * Patients with known blood disorders or malignancy. * Patients with history of blood transfusion in the last 90 days. * Patients with recent infections in the last 14 day
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ain Shams University
Cairo, Egypt