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New study tracks heart inflammation in teens after pfizer vaccine

NCT ID NCT05295290

First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 33 times

Summary

This study follows 319 people under 21 who developed heart inflammation (myocarditis or pericarditis) within 21 days of receiving the Comirnaty (Pfizer) COVID-19 vaccine. Researchers will monitor their heart function with imaging tests for up to 5 years to see if there are lasting effects. The goal is to better understand the risks and recovery from this rare side effect.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • Children's Healthcare of Atlanta - Arthur M. Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's Hospital

    New Orleans, Louisiana, 70118, United States

  • Children's Hospital of Michigan

    Detroit, Michigan, 48201, United States

  • Childrens Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Childrens Mercy Kansas City

    Kansas City, Missouri, 64108, United States

  • Childrens National Hospital

    Washington D.C., District of Columbia, 20010, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Connecticut Children's Medical Center

    Hartford, Connecticut, 06106, United States

  • Indiana University School of Medicine

    Indianapolis, Indiana, 46202, United States

  • MUSC Summey Medical Pavilion

    North Charleston, South Carolina, 20406, United States

  • Memorial Healthcare System

    Hollywood, Florida, 33021, United States

  • Northwell Health-Cohen Children's Medical Center

    New Hyde Park, New York, 11042, United States

  • Riley Hospital for Children at IU Health

    Indianapolis, Indiana, 46202, United States

  • The Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • University of Michigan Health Center

    Ann Arbor, Michigan, 48109, United States

  • Valley Children's Hospital

    Madera, California, 93636, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this study could clarify the long-term heart health risks after COVID-19 vaccination in young people, helping guide future vaccine safety recommendations.

What could go wrong

This is an observational study, not a treatment trial, so it won't offer new therapies. The findings may be limited by the small number of participants (319) and the lack of a comparison group.

Conditions

The condition(s) this trial relates to.

COVID-19 myocarditis pericarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.