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New hope for myeloma: phase 3 trial pits JNJ-79635322 against current drug

NCT ID NCT07518186

Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 28, 2026 · Updated 5 times

Summary

This phase 3 study compares a new injectable drug, JNJ-79635322, to an existing one, teclistamab, in about 700 people with multiple myeloma that has returned after 1 to 3 prior treatments. The goal is to see which drug works better at shrinking tumors and delaying disease progression. Participants must have had prior therapy including an anti-CD38 antibody and lenalidomide.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
JNJ-79635322 (injection)
What this could lead to
If it works, this could offer a more effective treatment option for people with multiple myeloma that has returned after initial therapies.
What could go wrong
This is an early-stage comparison; the new drug may not prove better than the existing one, and side effects are possible. Results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 700 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Dec 2032

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Documented diagnosis of multiple myeloma (MM) as defined by the criteria below: a. MM diagnosis according to the international myeloma working group (IMWG) diagnostic criteria, b. Measurable disease at screening as assessed by central laboratory * Received 1 to 3 prior lines of antimyeloma therapy, including an anti-cluster of differentiation (CD) 38 antibody and lenalidomide * Have an eastern cooperative oncology group (ECOG) performance status of 0 to 2 at screening and immediately before the first dose of study medication * Have clinical laboratory values meeting the criteria specified in the protocol during the screening and within 1 day of the start of administration of study treatment Exclusion criteria: * Major surgery, (for example, requiring general anesthesia) or significant traumatic injury within 2 weeks prior to first dose, or will not have fully recovered from surgery, or has surgery planned during the time the participant is expected to participate in the study * Suspected or known allergies, hypersensitivity, intolerance or other contraindications to the use of JNJ-79635322 or teclistamab or their excipients * Presence of any of the following: i. Any ongoing myelodysplastic syndrome or B-cell malignancy (other than MM); ii. Any history of malignancy, other than MM, that is considered at high risk of recurrence requiring systemic therapy; iii. Any active malignancy (that is, progressing or requiring treatment change in the last 24 months) other than MM * Known active or prior central nervous system (CNS) involvement or exhibits clinical signs of meningeal involvement of MM. If either is suspected, negative whole brain magnetic resonance imaging (MRI) and lumbar cytology are required

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple myeloma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    151 sites in 17 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • A O U Sant Orsola Malpighi

    RECRUITING

    Bologna, 40138, Italy

  • ASST Santi Paolo e Carlo

    RECRUITING

    Milan, 20153, Italy

  • ASST dei Sette Laghi, Ospedale di Circolo e Fonazione Macchi

    RECRUITING

    Varese, 21100, Italy

  • Alabama Oncology

    RECRUITING

    Birmingham, Alabama, 35211, United States

  • Alexandra General Hospital of Athens

    RECRUITING

    Athens, 11528, Greece

  • Ankara Etlik Sehir Hastanesi

    RECRUITING

    Ankara, 6170, Turkey (Türkiye)

  • Ankara University Medical Faculty

    RECRUITING

    Ankara, 06620, Turkey (Türkiye)

  • Asan Medical Center

    RECRUITING

    Seoul, 05505, South Korea

  • Asklepios Klinik Altona

    RECRUITING

    Hamburg, 22763, Germany

  • Astera Cancer Care

    RECRUITING

    East Brunswick, New Jersey, 08816, United States

  • Austin Hospital

    RECRUITING

    Heidelberg, 3084, Australia

  • Azienda Ospedaliero Universitaria Maggiore della Carita di Novara

    RECRUITING

    Novara, 28100, Italy

  • Azienda Sanitaria dell'Alto Adige - Ospedale di Bolzano

    RECRUITING

    Bolzano, 39100, Italy

  • Baylor University Medical Center

    RECRUITING

    Dallas, Texas, 75246, United States

  • Beijing Chaoyang Hospital

    RECRUITING

    Chaoyang District, 100020, China

  • Beverly Hills Cancer Center Clinical Research Advisors LLC

    RECRUITING

    Beverly Hills, California, 90211, United States

  • Bhagwan Mahaveer Cancer Hospital & Research Centre

    RECRUITING

    Jaipur, 302017, India

  • Bon Secours Saint Francis Cancer Center

    RECRUITING

    Greenville, South Carolina, 29607, United States

  • Box Hill Hospital

    RECRUITING

    Melbourne, 3128, Australia

  • CHRU Montpellier - Hopital Saint-Eloi

    RECRUITING

    Montpellier, 34295, France

  • CHRU de Tours

    RECRUITING

    Tours, 37000, France

  • CHU Amiens

    RECRUITING

    Amiens, 80000, France

  • CHU Bordeaux

    RECRUITING

    Talence, 33400, France

  • CHU Nantes - Hotel Dieu

    RECRUITING

    Nantes, 44000, France

  • CHU Toulouse

    RECRUITING

    Toulouse, 31300, France

  • Carmel Medical Center

    RECRUITING

    Haifa, 3436212, Israel

  • Casa di Cura La Maddalena

    RECRUITING

    Palermo, 90146, Italy

  • Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli

    RECRUITING

    Lublin, 20 090, Poland

  • Chang Kung Memorial Hospital

    RECRUITING

    Kaohsiung City, 833, Taiwan

  • Chiba Cancer Center

    RECRUITING

    Chiba, 260-8717, Japan

  • China Medical University Hospital

    RECRUITING

    Taichung, 40447, Taiwan

  • Chonnam National University Hwasun Hospital

    RECRUITING

    Hwasun, 58128, South Korea

  • Christus St. Vincent Regional Cancer Center

    RECRUITING

    Santa Fe, New Mexico, 87505, United States

  • Clinica Medica Sao Germano LTDA

    RECRUITING

    São Paulo, 04537 081, Brazil

  • Clinica Univ. de Navarra

    RECRUITING

    Pamplona, 31008, Spain

  • Colorado Blood Cancer Institute

    RECRUITING

    Denver, Colorado, 80218, United States

  • Dayton Physicians Network Urology

    RECRUITING

    Dayton, Ohio, 45415, United States

  • Deenanath Mangeshkar Hospital and Research Centre

    RECRUITING

    Pune, 411004, India

  • Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital

    RECRUITING

    Ankara, 06200, Turkey (Türkiye)

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Evangelismos S A

    RECRUITING

    Athens, 106 76, Greece

  • FN Hradec Kralove

    RECRUITING

    Hradec Králové, 500 05, Czechia

  • FN Plzen

    RECRUITING

    Plzen-Lochotin, 323 00, Czechia

  • Fakultni Nemocnice Ostrava

    RECRUITING

    Ostrava, 708 52, Czechia

  • Fakultni nemocnice Brno

    RECRUITING

    Brno, 625 00, Czechia

  • Fortis Memorial Research Institute

    RECRUITING

    Gurgaon, 122002, India

  • Franciscan Health

    RECRUITING

    Indianapolis, Indiana, 46237-8601, United States

  • Funfarme Sjrp

    RECRUITING

    São José do Rio Preto, 15090-000, Brazil

  • Gabrail Cancer Center

    RECRUITING

    Canton, Ohio, 44718, United States

  • Grupo ELORA Centro de Pesquisa e Ensino em Saude de Santa Catarina

    RECRUITING

    Florianópolis, 88020 210, Brazil

  • Gunma University Hospital

    RECRUITING

    Gunma, 371-0034, Japan

  • Highlands Oncology Group

    RECRUITING

    Springdale, Arkansas, 72762, United States

  • Hosp Clinico Univ de Salamanca

    RECRUITING

    Salamanca, 37007, Spain

  • Hosp Reina Sofia

    RECRUITING

    Córdoba, 14004, Spain

  • Hosp Univ Vall D Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hosp. Clinic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hosp. Clinico Univ. de Santiago

    RECRUITING

    Santiago de Compostela, 15706, Spain

  • Hosp. San Pedro de Alcantara

    RECRUITING

    Cáceres, 10003, Spain

  • Hosp. Univ. 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hosp. Univ. Marques de Valdecilla

    RECRUITING

    Santander, 39008, Spain

  • Hosp. Virgen Del Rocio

    RECRUITING

    Seville, 41013, Spain

  • Hosp. de Jerez de La Frontera

    RECRUITING

    Jerez de la Frontera, 11407, Spain

  • Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer

    RECRUITING

    Curitiba, 81520-060, Brazil

  • IRCCS Istituto Tumori Giovanni Paolo II

    RECRUITING

    Bari, 70124, Italy

  • Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences

    RECRUITING

    Tijian, 300020, China

  • Instituto Joinvilense de Hematologia e Oncologia Ltda Centro de Hematologia e Oncologia

    RECRUITING

    Joinville, 89201-260, Brazil

  • Irmandade Santa Casa de Misericordia de Porto Alegre

    RECRUITING

    Porto Alegre, 90050 170, Brazil

  • Istanbul Florance Nightingale Hospital

    RECRUITING

    Istanbul, 34381, Turkey (Türkiye)

  • Izmir Tinaztepe University Galen Hospital

    RECRUITING

    Izmir, 35001, Turkey (Türkiye)

  • Joe Arrington Cancer Research Treatment Center

    RECRUITING

    Lubbock, Texas, 79410, United States

  • Kanagawa Cancer Center

    RECRUITING

    Yokohama, 241 8515, Japan

  • Karmanos Cancer Institute

    RECRUITING

    Detroit, Michigan, 48201, United States

  • LSU Health Feist Weiller Cancer Center

    RECRUITING

    Shreveport, Louisiana, 71103, United States

  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island

    RECRUITING

    Mineola, New York, 11501, United States

  • Liv Hospital Ankara

    RECRUITING

    Ankara, 06680, Turkey (Türkiye)

  • M S Ramaiah Medical College and Hospital

    RECRUITING

    Bengaluru, 560054, India

  • MTZ Clinical Research Powered by Pratia

    RECRUITING

    Warsaw, 02-172, Poland

  • Macquarie University Hospital

    RECRUITING

    Macquarie University, 2109, Australia

  • Matsuyama Red Cross Hospital

    RECRUITING

    Matsuyama, 790-8524, Japan

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Mayo Clinic 1

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic Jacksonville

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Medipol Mega University Hospital

    RECRUITING

    Istanbul, 34214, Turkey (Türkiye)

  • Memorial Antalya Hospital

    RECRUITING

    Antalya, 07025, Turkey (Türkiye)

  • Memorial Cancer Institute

    RECRUITING

    Pembroke Pines, Florida, 33026, United States

  • Mersin University Medical Faculty

    RECRUITING

    Mersin, 33110, Turkey (Türkiye)

  • Mission Cancer Blood University of Iowa Health Care

    RECRUITING

    Waukee, Iowa, 50263, United States

  • NYU Langone Health Manhattan

    RECRUITING

    New York, New York, 10016, United States

  • National Cancer Center

    RECRUITING

    Goyang-si, 10408, South Korea

  • National Cheng Kung University Hospital

    RECRUITING

    Tainan, 70403, Taiwan

  • National Hospital Organization Kyushu Medical Center

    RECRUITING

    Fukuoka, 810 8563, Japan

  • National Hospital Organization Okayama Medical Center

    RECRUITING

    Okayama, 701-1192, Japan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 100, Taiwan

  • Nebraska Cancer Specialists

    RECRUITING

    Omaha, Nebraska, 68130, United States

  • New York Cancer and Blood Specialists

    RECRUITING

    Shirley, New York, 11967, United States

  • New York Oncology Hematology

    RECRUITING

    Albany, New York, 12208, United States

  • Nil Ratan Sircar Medical College and Hospital

    RECRUITING

    Kolkata, 700014, India

  • Norton Cancer Institute

    RECRUITING

    Louisville, Kentucky, 40207, United States

  • Ondokuz Mayis University

    RECRUITING

    Samsun, 55420, Turkey (Türkiye)

  • Ospedale Infermi Rimini

    RECRUITING

    Rimini, 47900, Italy

  • Ospedale San Raffaele di Milano

    RECRUITING

    Milan, 20132, Italy

  • Peking Union Medical College Hospital

    RECRUITING

    Beijing, 100006, China

  • Peking University First Hospital

    RECRUITING

    Beijing, 100034, China

  • Peking University Shenzhen Hospital

    RECRUITING

    Shenzhen, 518036, China

  • Port Macquarie Base Hospital

    RECRUITING

    Port Macquarie, 2444, Australia

  • Pratia Onkologia Katowice

    RECRUITING

    Katowice, 40 519, Poland

  • Rabin Medical Center

    RECRUITING

    Petah Tikva, 4941492, Israel

  • Rajiv Gandhi Cancer Institute and Research Centre

    RECRUITING

    New Delhi, 110085, India

  • Rambam Med.Center - Hematology Institute

    RECRUITING

    Haifa, 3109601, Israel

  • Real e Benemerita Associacao Portuguesa de Beneficencia

    RECRUITING

    São Paulo, 01323 001, Brazil

  • Rush University System for Health

    RECRUITING

    Chicago, Illinois, 60607, United States

  • Samson Assuta Ashdod University Hospital

    RECRUITING

    Ashdod, 7747629, Israel

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • Sapporo City General Hospital

    RECRUITING

    Sapporo, 060-8604, Japan

  • Seoul National University Bundang Hospital

    RECRUITING

    Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, 03080, South Korea

  • Sheba Medical Center

    RECRUITING

    Ramat Gan, 5266202, Israel

  • Shonan Kamakura General Hospital

    RECRUITING

    Kamakura-shi, 247-8533, Japan

  • Sichuan Academy of Medical Science Sichuan Provincial People's Hospital

    RECRUITING

    Chengdu, 610072, China

  • Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein

    RECRUITING

    São Paulo, 05651 901, Brazil

  • Specjalistyczny Szpital im dra Alfreda Sokolowskiego w Walbrzychu

    RECRUITING

    Wałbrzych, 58 309, Poland

  • St Vincent s Hospital Sydney

    RECRUITING

    Darlinghurst, 2010, Australia

  • Sun Yat Sen University Cancer Center

    RECRUITING

    Guangzhou, 510710, China

  • Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy

    RECRUITING

    Bydgoszcz, 85 168, Poland

  • Taichung Veterans General Hospital

    RECRUITING

    Taichung, 40705, Taiwan

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 112, Taiwan

  • Tata Medical Center

    RECRUITING

    Kolkata, 700156, India

  • Tel Aviv Sourasky Medical Center

    RECRUITING

    Tel Aviv, 6423906, Israel

  • The Cancer Institute Hospital of JFCR

    RECRUITING

    Tokyo, 135-8550, Japan

  • The Catholic University of Korea Seoul St Marys Hospital

    RECRUITING

    Seoul, 06591, South Korea

  • The Christ Hospital

    RECRUITING

    Cincinnati, Ohio, 45069, United States

  • The First Affiliated Hospital of Wenzhou Medical University

    RECRUITING

    Wenzhou, 325000, China

  • The First Affliated Hospital Of Nanchang University

    RECRUITING

    Nanchang, 330006, China

  • The First Hospital of Jilin University

    RECRUITING

    Changchun, 130061, China

  • The Second Affiliated Hospital of Xi'an Jiaotong University

    RECRUITING

    Xi'an, 710004, China

  • Tianjin Medical University Cancer Institute and Hospital

    RECRUITING

    Tianjin, 300060, China

  • UC Irvine Health Chao Family Comprehensive Cancer Center and Ambulatory Care

    RECRUITING

    Irvine, California, 92612, United States

  • Universitaetsklinik Tuebingen

    RECRUITING

    Tübingen, 72076, Germany

  • Universitaetsklinikum Freiburg

    RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • Universitaetsklinikum Hamburg Eppendorf

    RECRUITING

    Hamburg, 20251, Germany

  • University General Hospital Attikon General Hospital Of West Attica H Agia Varvara

    RECRUITING

    Athens, 124 62, Greece

  • University General Hospital of Ioannina

    RECRUITING

    Ioannina, 455 00Q, Greece

  • University Hospital Kyoto Prefectural University of Medicine

    RECRUITING

    Kyoto, 602-8566, Japan

  • University Of Minnesota Medical Center

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

  • University of California Irvine Medical Center

    RECRUITING

    Orange, California, 92868, United States

  • University of Connecticut Health Center

    RECRUITING

    Farmington, Connecticut, 06030, United States

  • University of Iowa Hospitals and Clinics

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • Uniwersyteckie Centrum Kliniczne

    RECRUITING

    Gdansk, 80 214, Poland

  • Utah Cancer Specialists

    RECRUITING

    Salt Lake City, Utah, 84102, United States

  • VFN Praha

    RECRUITING

    Prague, 128 08, Czechia

  • Valkyrie Clinical Trials

    RECRUITING

    Los Angeles, California, 90067, United States

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