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Mulberry leaf extract boosts weight loss in metformin users, study finds

NCT ID NCT07451639

Disease control Sponsor: Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a mulberry leaf extract to metformin helps overweight adults with early metabolic issues lose more weight. Fifty adults took either the extract or a placebo for 12 weeks while continuing their usual diet and activity. Researchers measured changes in weight, waist size, blood sugar, and cholesterol to see if the supplement offered extra benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Mar 2023

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Metformin prescribed as part of routine clinical management for early metabolic abnormalities * Stable glucose control for at least six months prior to enrolment Exclusion Criteria: * pregnancy or lactation * severe infection * advanced hepatic or renal insufficiency * active malignancy * any condition deemed incompatible with study participation.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Weight management

Contacts and locations

Locations

  • Azienda Ospedaliera Universitaria Pliclinico Paolo Giaccone

    Palermo, 90127, Italy

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