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New gel aims to soothe vaginal dryness without hormones

NCT ID NCT05913479

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a gel called Mucogyne Gel as a moisturizer for women with vaginal dryness, no matter the cause. Thirty-four women applied the gel inside the vagina 2 to 3 times a week for 5 weeks. Doctors checked vaginal health and women reported pain levels to see if the gel helped.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mucogyne Gel (a moisturizing gel applied inside the vagina)
What this could lead to
If it works, this gel could offer a non-hormonal option to relieve vaginal dryness and discomfort.
What could go wrong
This is a small, completed study with only 34 women. Results may not apply to everyone, and the gel may not work for all causes of dryness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

Oct 2023

Finished

Jan 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Women with the following conditions: * ≥ 18 years of age at inclusion with vaginal dryness, irrespective of the cause (which may or may not be accompanied by irritation of the vulva, discomfort, or itchiness). * Having a Vaginal Health Index Score (VHIS) \<15 associated to pain and/or dyspareunia feeling. * Subject agrees to not use any lubricant, local estrogens, or other vaginal product during the study. * Subject agrees to not modify their intimate hygiene products. * Able to understand and sign the informed consent form for study enrolment. * Subject able to comply with study requirements, as defined in the protocol. * Subject affiliated to a health social security system. Exclusion Criteria: Women with the following conditions: * General: * Pregnancy (subject of childbearing potential must not be pregnant and must agree to avoid pregnancy during the study by using an effective birth control method from at least one month before D0 (V0) and throughout the duration of the study). * Participating at the same time in another interventional trial within the four previous weeks and during the study period, being in an exclusion period for a previous study. * Deprived of freedom by administrative or legal decision or under guardianship. * Subject in a social or sanitary establishment. * Subject suspected to be non-compliant according to the investigator's judgment. * Subject in an emergency situation. * Linked to subject's status: * Known hypersensitivity to one of MUCOGYNE® Gel components. * Subject with a known vaginal pathology (clinical diagnosis only) other than vaginal dryness/atrophy. * Linked to previous or ongoing treatments: * Subject with a condition or receiving a medication which, in the investigator's judgment, put the subject at undue risk. * Subject suffering from systemic diseases and/or using concurrent therapy that may interfere with the evaluation of the study results. * Subject undergoing a topical treatment on the test area or a systemic treatment: corticosteroids during the 2 previous weeks and during the study; retinoids and/or immunosuppressors during the 1,5 previous months and during the study; subject having started or changed her oral contraceptive or any other hormonal treatment during the one previous month.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Dr Christiane ARMAND's medical office

    Écully, 69130, France

  • Dr Paul Lefevre's medical office

    Caen, 14000, France

  • Dr Thierry KELLER's medical office

    Colmar, 68000, France

  • Sihame MOKHBAT's office

    Paris, 75018, France

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