New gel aims to soothe vaginal dryness without hormones
NCT ID NCT05913479
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a gel called Mucogyne Gel as a moisturizer for women with vaginal dryness, no matter the cause. Thirty-four women applied the gel inside the vagina 2 to 3 times a week for 5 weeks. Doctors checked vaginal health and women reported pain levels to see if the gel helped.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Mucogyne Gel (a moisturizing gel applied inside the vagina)
- What this could lead to
- If it works, this gel could offer a non-hormonal option to relieve vaginal dryness and discomfort.
- What could go wrong
- This is a small, completed study with only 34 women. Results may not apply to everyone, and the gel may not work for all causes of dryness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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34 people
The number who actually took part.
- Started
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Oct 2023
- Finished
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Jan 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Women with the following conditions: * ≥ 18 years of age at inclusion with vaginal dryness, irrespective of the cause (which may or may not be accompanied by irritation of the vulva, discomfort, or itchiness). * Having a Vaginal Health Index Score (VHIS) \<15 associated to pain and/or dyspareunia feeling. * Subject agrees to not use any lubricant, local estrogens, or other vaginal product during the study. * Subject agrees to not modify their intimate hygiene products. * Able to understand and sign the informed consent form for study enrolment. * Subject able to comply with study requirements, as defined in the protocol. * Subject affiliated to a health social security system. Exclusion Criteria: Women with the following conditions: * General: * Pregnancy (subject of childbearing potential must not be pregnant and must agree to avoid pregnancy during the study by using an effective birth control method from at least one month before D0 (V0) and throughout the duration of the study). * Participating at the same time in another interventional trial within the four previous weeks and during the study period, being in an exclusion period for a previous study. * Deprived of freedom by administrative or legal decision or under guardianship. * Subject in a social or sanitary establishment. * Subject suspected to be non-compliant according to the investigator's judgment. * Subject in an emergency situation. * Linked to subject's status: * Known hypersensitivity to one of MUCOGYNE® Gel components. * Subject with a known vaginal pathology (clinical diagnosis only) other than vaginal dryness/atrophy. * Linked to previous or ongoing treatments: * Subject with a condition or receiving a medication which, in the investigator's judgment, put the subject at undue risk. * Subject suffering from systemic diseases and/or using concurrent therapy that may interfere with the evaluation of the study results. * Subject undergoing a topical treatment on the test area or a systemic treatment: corticosteroids during the 2 previous weeks and during the study; retinoids and/or immunosuppressors during the 1,5 previous months and during the study; subject having started or changed her oral contraceptive or any other hormonal treatment during the one previous month.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dr Christiane ARMAND's medical office
Écully, 69130, France
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Dr Paul Lefevre's medical office
Caen, 14000, France
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Dr Thierry KELLER's medical office
Colmar, 68000, France
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Sihame MOKHBAT's office
Paris, 75018, France
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