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Gum graft showdown: synthetic vs. natural tissue in recession repair

NCT ID NCT04800250

Disease control Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a synthetic gum graft (Mucogain matrix) could be a good alternative to the standard connective tissue graft for treating receding gums. The goal was to see if the synthetic option covers the exposed tooth root just as well, but with less pain and fewer complications. The study planned to include 8 non-smoking adults with specific types of gum recession, but it was terminated early.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

8 people

The number who actually took part.

Started

Jul 2023

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Patient with 3 contiguous, symmetrical and bilateral RTI Cairo gingival recessions (Miller Class 1) (i.e. 6 recessions) * Patient non-smoker * Patient affiliated to social security * Patient signed informed consent. Exclusion criteria: * Patient with or having presented an acute or chronic severe cardiovascular, kidney, liver, gastrointestinal, allergic, endocrine, neuropsychiatric pathology, developed cancer of the upper aero digestive tract treated with radiotherapy * Patient with severe hemorrhinopathy * Patient treated with oral retinoids, bisphosphonates, oral or anticonvulsants * Patient who has taken steroidal or non-steroidal anti-inflammatory therapy, anti-cancer or immunosuppressive chemotherapy within the last 6 months. * Patient with contraindication to necessary and pre-, per- or post-operative treatments * Follow-up of the patient seemed difficult by the investigator * Patient with insufficient oral hygiene incompatible with oral surgery

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Conditions

The condition(s) this trial relates to.

gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession

Contacts and locations

Locations

  • CHU de Nice

    Nice, Provence-Alpes-Côte d'Azur Region, 06000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.