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Can MRI spot radiation damage in the mouth? new study aims to find out

NCT ID NCT06586892

Knowledge-focused Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study will test whether special MRI scans can accurately detect and track damage to the mouth and jaw caused by radiation therapy for head and neck cancers. Researchers will enroll 300 adults undergoing radiation, with some receiving additional MRI scans before and after treatment. The goal is to validate MRI as a reliable tool for diagnosing osteoradionecrosis, a serious complication, and to improve monitoring of soft tissue health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MRI scan
What this could lead to
If successful, this could provide a reliable way to detect and monitor mouth and jaw damage from radiation, helping doctors treat it earlier.
What could go wrong
This is an early validation study, not a treatment trial. The MRI method may not prove accurate enough for routine use, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Dec 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

MD Anderson Cancer Center

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Provide signed and dated informed consent form. * Aged 18 years or older. * Have histologic evidence of malignant neoplasm that may have been obtained from the primary tumor or metastatic lymph node. * Have a clinical decision made to receive external beam radiation therapy (EBRT) with curative intent, with or without concomitant chemotherapy. * Have a good performance status (ECOG score 0-2) evaluated during screening (4 weeks prior to baseline imaging). * Be willing to comply with all study procedures. * Be willing to participate for the duration of the study. * Have elevated dosimetric risk mainly characterized by any of the following criteria: * D30\>50Gy: 30% of the whole-mandible volume received a dose greater than 50 Gy * V44 ≥ 42%: at least 42% of the volume received a dose of 44 Gy or more or * V58 ≥ 25%: at least 25% of the volume received a dose of 58 Gy or more. Exclusion Criteria: Unable to tolerate DW-MRI or DCE-MRI; * Having an estimated GFR \< 30 ml/min/1.73 m2; * Contraindication to MRI (e.g., non-MRI compatible metallic implants) * Pregnant females * Unable or unwilling to give written, informed consent to undergo MRI imaging. * Claustrophobia * Unable to obtain imaging studies of adequate quality to assess imaging-based biomarkers.

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Conditions

The condition(s) this trial relates to.

head and neck cancer mouth disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Orodental injury

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The University of Texas M. D. Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

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