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Gargle away the sniffles? study tests mouthwash against cold and flu

NCT ID NCT06479226

Symptom relief Sponsor: Colgate Palmolive Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether gargling with a mouthwash containing cetylpyridinium chloride and zinc could reduce cold and flu symptoms. 150 healthy adults either brushed their teeth alone or brushed and then gargled with the mouthwash twice daily for 90 days. Participants tracked their symptoms daily. The goal was to see if the mouthwash group had more symptom-free days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cetylpyridinium chloride (0.075%) and zinc mouthwash
What this could lead to
If it works, this could offer a simple, low-cost way to reduce cold and flu symptoms during the season.
What could go wrong
This is a small, completed study in healthy adults, so results may not apply to everyone. The effect may be modest and not prevent illness entirely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

150 people

The number who actually took part.

Started

Jun 2022

Finished

Oct 2022

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Good systemic general health as determined by study investigators; Availability of 90 days to participate in the study; Exclusion Criteria: * those participating in any other clinical study; * Pregnant or breastfeeding; * Presence a history of allergies to oral hygiene products, personal hygiene products, or their ingredients; * Have mouth irritation or use oral anesthetic sprays; * Have diabetes; * Be undergoing extensive dental treatment or oral surgery during the study; * Present immunocompromised (HIV, AIDS, immunosuppressive drug therapy); * Use complete dentures; * Do not have carpal tunnel syndrome or arthritis in the hands. * Participant who substantially fails to follow the required protocols; * Participant who fails to attend scheduled appointments; * Participant who is treated, during the study period, with medications that may interfere with the parameters being analyzed in the study; * Participant who is treated by a medical or dental service, and this may interfere with the parameters being analyzed in the study; * Participant who develops serious adverse reactions. * The participant who chooses to terminate their participation in the study; * Participant reports being pregnant during the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • Federal University of Pelotas

    Pelotas, Rio Grande do Sul, Brazil

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