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Mind over matter: brain training may restore hand function after stroke

NCT ID NCT04847089

Symptom relief Sponsor: Mälardalen University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether imagining hand movements while getting real-time brain feedback could help stroke survivors with arm weakness. Sixteen people who had a stroke at least six months earlier practiced motor imagery with a brain-computer interface for four weeks. The goal was to see if this training could improve hand function and brain activity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Motor imagery brain-computer interface (BCI) training
What this could lead to
If it works, this could point toward a new rehabilitation method to help stroke survivors regain hand movement without drugs or surgery.
What could go wrong
This was a very small, early study with only 16 participants and no control group, so results may not apply widely. The training is also intensive and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Apr 2022

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \> 6 months since first time stroke onset and with remaining hemiparesis in upper extremity; able to participate fully in the intervention, able to perform Functional Magnetic Resonance Imaging (fMRI); able to passively extend the wrist 15 degrees and extend fingers fully with a neutral position of the wrist. In addition, participants need to be able to voluntarily control the power of their grip when requested according to the Visuomotor force tracking method and/or according to the clinical assessment of a therapist (while holding the patient´s hand). According to the Fugl- Meyer Upper Extremity (UE) scale participants should accomplish \<14 points on the hand subscale and \<2 points in finger flexion and extension (C) in addition to \< 47 points on the total motor score (equivalent to moderate disability in the upper extremity. Exclusion Criteria: * other neurological or musculoskeletal disease/injury, or contagious disease. * If the research person is regularly treated with botulinum toxin in the upper extremity, 3 weeks should have passed before the first baseline assessment. * current or history of epilepsy, * severe hearing or visual impairments, * metal implants in the brain/skull cochlear implants, * any implanted neurostimulator, cardiac pacemaker or cardiac implants of metal, infusion device, * any other neurological disorder, * pregnancy, * current or history of severe psychiatric disorder with need for pharmacological treatment

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Conditions

The condition(s) this trial relates to.

hemiplegia Paresis stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemiparesis Stroke

Contacts and locations

Locations

  • Department of rehabilitation medicine at Danderyd University

    Stockholm, 18288, Sweden

  • Stockholn University Brain Imaging Centre

    Stockholm, 11418, Sweden

  • Sweden Mälardalen University

    Västerås, 72123, Sweden

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