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Finding the sweet spot: safer morphine dosing for hip surgery pain

NCT ID NCT06878014

Symptom relief Sponsor: Medical University of Silesia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares different doses of morphine given with spinal anesthesia during total hip replacement. The goal is to find a dose that provides good pain relief for up to 24 hours while minimizing side effects like breathing problems, nausea, and itching. About 120 adults undergoing hip replacement will take part, and their pain levels and side effects will be tracked for 48 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
morphine (given into the spinal fluid)
What this could lead to
If successful, this could help doctors choose the safest and most effective dose of spinal morphine for hip replacement pain, reducing serious side effects like breathing trouble.
What could go wrong
This is a small, early-phase trial (120 people) focused on dosing, not a new treatment. Results may not apply to all patients, and morphine still carries risks like nausea, itching, and rare breathing depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Informed consent to participate in trial * Qualification for total hip replacement surgery * ASA physical status I-III * BMI 19-30 * Lack of contraindications for drugs and interventions used in trial Exclusion Criteria: * Incapability to provide informed consent * Contraindications for spinal anesthesia * Preoperative chronic pain * Chronic use of analgesics * Obesity (BMI\>30) * Allergies and other contraindications for drugs used in trial * Mental or physical incapability to operate PCA syringe pump

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adverse anesthesia outcome Analgesics, opioid Anesthesia, spinal Total hip replacement

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Uniwersytecki Szpital Kliniczny nr 1 im. prof. Tadeusza Sokołowskiego PUM w Szczecinie

    NOT_YET_RECRUITING

    Szczecin, West Pomeranian Voivodeship, 70-204, Poland

  • Wojewódzki Szpital Specjalistyczny nr 5 im. św. Barbary

    RECRUITING

    Sosnowiec, Silesian Voivodeship, 41-214, Poland

  • Zespół Opieki Zdrowotnej w Końskich

    RECRUITING

    Gmina Końskie, Świętokrzyskie Voivodeship, 26-200, Poland

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