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Scientists dive into DNA of rare lymphoma to predict outcomes

NCT ID NCT05700149

Knowledge-focused Sponsor: International Extranodal Lymphoma Study Group (IELSG) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at tumor samples from 300 people with nodal marginal zone lymphoma, a rare blood cancer. Researchers want to find genetic patterns that help predict how the disease will behave. The goal is to better understand the disease and improve future treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to more personalized treatment strategies for nodal marginal zone lymphoma.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly benefit participants. Results may not change clinical practice immediately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with diagnosis of NMZL on lymph node histology

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female adults 18 years or older 2. Diagnosis of NMZL on lymph node histology after Jan 1st, 2000 3. Availability of tumor material from lymph node (either frozen or FFPE) collected when the patient was treatment naïve 4. Availability of the baseline and follow-up annotations Exclusion Criteria: 1\. Nodal spread of a clinically occult extranodal MZL (this must have been ruled out by carefully evaluating the extranodal tissues draining to the involved lymph nodes by imaging or endoscopy)

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Conditions

The condition(s) this trial relates to.

Lymphoma, B-Cell, Marginal Zone nodal marginal zone B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nodal marginal zone lymphoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    50 sites in 15 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AO SS Antonio e Biagio e C. Arrigo

    RECRUITING

    Alessandria, AL, 15121, Italy

  • AOU Maggiore della Carità

    RECRUITING

    Novara, 28100, Italy

  • AOU Policlinico Vittorio Emanuele, Presidio Ferrarotto

    RECRUITING

    Catania, CT, 95123, Italy

  • ASST Grande Ospedale Metropolitano Niguarda

    RECRUITING

    Milan, MI, 20162, Italy

  • ASST Papa Giovanni XXIII

    RECRUITING

    Bergamo, BG, 24127, Italy

  • ASST degli Spedali Civili di Brescia

    RECRUITING

    Brescia, BS, 25123, Italy

  • ASST dei Sette Laghi - Ospedale di Circolo di Varese

    RECRUITING

    Varese, VA, 21100, Italy

  • AUSL IRCCS di Reggio Emilia, Arcispedale S. Maria Nuova

    RECRUITING

    Reggio Emilia, RE, 42123, Italy

  • Azienda Ospedaliera Papardo

    RECRUITING

    Messina, ME, 98158, Italy

  • Azienda Ospedaliera Universitaria Careggi

    RECRUITING

    Florence, FI, 50134, Italy

  • Azienda Ospedaliera Universitaria Federico II

    RECRUITING

    Naples, 80131, Italy

  • Azienda Ospedaliero Universitaria di Ferrara

    RECRUITING

    Cona, FE, 44124, Italy

  • Azienda Sanitaria Locale di Pescara

    RECRUITING

    Pescara, PE, 65124, Italy

  • CHU Grenoble Alpes

    RECRUITING

    Grenoble, 38043, France

  • Centro di Riferimento Oncologico

    RECRUITING

    Aviano, PN, 33081, Italy

  • Chonnam National University Hwasun Hospital

    RECRUITING

    Jeollanam-do, 58128, South Korea

  • Clatterbridge Cancer Centre Liverpool

    RECRUITING

    Liverpool, L7 8YA, United Kingdom

  • Fondazione IRCCS Policlinico San Matteo

    RECRUITING

    Pavia, PV, 27100, Italy

  • Fondazione PTV - Policlinico Tor Vergata

    RECRUITING

    Rome, RM, 00133, Italy

  • Fondazione Policlinico Univeristario A. Gemelli, IRCCS, Università Cattolica S. Cuore

    RECRUITING

    Rome, RM, 00168, Italy

  • Hematology Center after Prof. Yeolyan

    RECRUITING

    Yerevan, Armenia

  • Hospital Clinic I Provincial de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Italiano de Buenos Aires

    RECRUITING

    Buenos Aires, C1199ABB, Argentina

  • Hospital Universitari de Bellvitge / Institut Català d'Oncologia

    RECRUITING

    L'Hospitalet de Llobregat, 08907, Spain

  • Hospital del Mar

    RECRUITING

    Barcelona, 08003, Spain

  • Hôpitaux Universitaires Genevois

    RECRUITING

    Geneva, Switzerland

  • IEO Istituto Europeo di Oncologia

    RECRUITING

    Milan, MI, 20141, Italy

  • IRCCS - Azienda Ospedaliero-Universitaria di Bologna

    RECRUITING

    Bologna, 40138, Italy

  • IRCCS Ospedale San Raffaele

    RECRUITING

    Milan, MI, 20132, Italy

  • Institut Universitaire du Cancer de Toulouse

    RECRUITING

    Toulouse, 31059, France

  • Istituto Tumori "Giovanni Paolo II" I.R.C.C.S.

    RECRUITING

    Bari, BA, 70124, Italy

  • Kantonsspital St. Gallen

    RECRUITING

    Sankt Gallen, 9007, Switzerland

  • Leicester Royal Infirmary

    RECRUITING

    Leicester, LE1 5WW, United Kingdom

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Norfolk and Norwich University Hospital

    RECRUITING

    Norwich, NR4 7UY, United Kingdom

  • Ohio Health Riverside Methodist Hospital

    RECRUITING

    Columbus, Ohio, 43214, United States

  • Oncology Institute of Southern Switzerland and Institute of Oncology Research

    RECRUITING

    Bellinzona, 6500, Switzerland

  • Oxford University Hospitals

    RECRUITING

    Oxford, OX3 7LE, United Kingdom

  • Portuguese Institute of Oncology

    RECRUITING

    Lisbon, 1099-023, Portugal

  • Princess Margaret Cancer Centre

    RECRUITING

    Toronto, Canada

  • Rijnstate Hospital

    RECRUITING

    Arnhem, Netherlands

  • Royal Bournemouth Hospital

    RECRUITING

    Bournemouth, BH7 7DW, United Kingdom

  • Sapienza University - AOU Policlinico Umberto I

    RECRUITING

    Rome, RM, 00161, Italy

  • Tata Memorial Hospital

    RECRUITING

    Mumbai, India

  • University Clinical Center, Medical University of Gdansk

    RECRUITING

    Gdansk, 80-211, Poland

  • University Hospital Basel

    RECRUITING

    Basel, Switzerland

  • University Hospital Centre Zagreb

    RECRUITING

    Zagreb, 10000, Croatia

  • University Hospital Zurich

    RECRUITING

    Zurich, 8091, Switzerland

  • University of Miami

    RECRUITING

    Miami, Florida, 33136, United States

  • Weill Cornell Medical

    RECRUITING

    New York, New York, 10065, United States

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Other studies related to the condition(s) this trial covers.