Can antibodies and vaccine work together? new study investigates
NCT ID NCT04852978
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether giving Regeneron's antibody treatment (casirivimab+imdevimab) along with the Moderna COVID-19 vaccine changes how well the vaccine works. About 295 healthy adults took part. Researchers measured immune responses and checked safety to see if the timing between the antibody shot and the vaccine matters.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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295 people
The number who actually took part.
- Started
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Apr 2021
- Finished
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Nov 2022
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Key Inclusion Criteria: 1. Healthy or has chronic medical condition(s) that are stable and well-controlled in the opinion of the investigator and that are not likely to require significant medical intervention through the end of study 2. Willing and able to comply with study visits and study-related procedures, including compliance with site precautionary requirements related to SARS-CoV-2 infection and transmission Key Exclusion Criteria: 1. Positive RT-PCR test result for SARS-CoV-2 infection at screening or baseline 2. Positive serology test result for anti-SARS-CoV-2 antibodies at screening or baseline 3. COVID-19 diagnosis, positive SARS-CoV-2 infection, or positive SARS-CoV-2 serology at any time prior to screening 4. Previously received an investigational, authorized, or approved coronavirus vaccine (eg, SARS-CoV-2 vaccine, MERS-CoV vaccine) 5. Currently enrolled in, or has plans to enroll in, any interventional study to prevent or treat COVID-19 6. Received investigational or approved passive antibodies for SARS-CoV-2 infection prophylaxis ad defined in the protocol 7. Received intravenous immunoglobulin (IVIG) or blood products in the last 3 months 8. Any physical examination findings and/or history of any illness that, in the opinion of the study investigator, might confound the results of the study or pose an additional risk to the subject by study participation 9. History of clinically significant cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, psychiatric or neurological disease, as assessed by the investigator, that may confound the results of the study or pose an additional risk to the subject by study participation 10. Medically attended acute illness or hospitalization (ie, \>24 hours) for any reason within 30 days prior to screening 11. Clinical history of myocarditis and/or pericarditis Note: Other protocol-defined Inclusion/ Exclusion Criteria apply
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Regeneron Research Site
Little Rock, Arkansas, 72211, United States
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Regeneron Research Site
Rogers, Arkansas, 72758, United States
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Regeneron Research Site
Hialeah, Florida, 33012, United States
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Regeneron Research Site
Miami, Florida, 33186, United States
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Regeneron Research Site
Orlando, Florida, 32789, United States
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Regeneron Research Site
Dayton, Ohio, 45417, United States
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