Could a simple pill improve uterine niche surgery outcomes?
NCT ID NCT07271056
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether taking misoprostol under the tongue two hours before surgery for uterine niche (a scar complication after C-section) helps reduce postmenstrual spotting. Fifty-six women with prior C-section and abnormal bleeding were randomly assigned to receive misoprostol or a placebo. The goal was to see if the drug makes the surgery safer and more effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- misoprostol
- What this could lead to
- If it works, this could offer a simple way to improve recovery and reduce bleeding after surgery for uterine niche.
- What could go wrong
- This is a small, completed trial with only 56 participants, so results may not apply to everyone. Misoprostol can cause side effects like cramping or nausea.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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56 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ≥1 previous cesarean section * Post cesarean section uterine niche confirmed by saline infusion sonohysterography (niche depth ≥2 mm) * Residual myometrial thickness ≥2.5 mm as confirmed by saline infusion sonohysterography * Regular cycles * Abnormal uterine bleeding for ≥3 consecutive cycles * Post menstrual spotting or brownish discharge ≥2 days * Total monthly bleeding duration \>7 days Exclusion Criteria: * Irregular cycles * Amenorrhea * Abnormal cervical cytology * Acute or chronic cervicitis * Pelvic inflammatory disease * Endometrial polyps * Uterine fibroids * Contraindications to spinal or general anesthesia * Refusal to participate
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Benha Univesity Hospital
Banhā, Qalyubia Governorate, 13512, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a single dose extend Post-Cesarean pain relief?
- Could having a partner present during emergency C-Sections improve Mothers' mental health?
- When pain strikes during C-Section: what Women's stories reveal
- Which drug stops Post-Birth bleeding better? a Head-to-Head test