Which route for misoprostol best cuts bleeding in C-Sections?
NCT ID NCT07728084
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial tests whether giving misoprostol into the uterus or through the rectum better reduces blood loss during and after planned cesarean delivery. One hundred forty low-risk pregnant women will receive the drug by one of these two routes. The goal is to find the most effective way to prevent postpartum hemorrhage, a leading cause of maternal complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- misoprostol tablets given either rectally or into the uterus
- What this could lead to
- If one method works better, it could lead to a safer, simpler way to prevent dangerous bleeding after cesarean delivery.
- What could go wrong
- This is a small, single-center trial, so results may not apply to all women. Both routes can cause side effects like shivering or fever.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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140 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Low risk women with singleton living fetus scheduled for elective cesarean delivery * American Society of Anesthesiologists (ASA) physical status I or II * Age: 20-40 years * Parity: 0-3 * Gestational age: 37-40 completed weeks * Body mass index (BMI): 18-30 kg/m² * Planned spinal anesthesia * Provision of informed consent Exclusion Criteria: * High risk pregnancies (anemia, renal disease, cardiac disease, hepatic disease, coagulopathies) * Increased risk for obstetric hemorrhage (placenta previa, placenta accreta spectrum, polyhydramnios, history of PPH, uterine rupture, uterine fibroids) * Allergy to prostaglandins or prostaglandin contraindications (e.g., asthma) * Complicated cesarean sections (bladder/ureteric injury, intestinal injury, massive intraoperative bleeding) * Known fetal or structural anomalies * Refusal to participate
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cairo University
Cairo, Cairo Governorate, 12111, Egypt