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Heart surgery brain fog: scientists hunt for a blood test to predict it

NCT ID NCT07231731

Knowledge-focused Sponsor: Osijek University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 48 older adults having heart bypass surgery to see if a small molecule called microRNA-151-5p is linked to memory and thinking problems after the operation. Researchers measured levels of this molecule and inflammation in the blood before and after surgery, and tested thinking skills daily. The goal was to understand why some people experience cognitive decline after heart surgery and find early warning signs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

48 people

The number who actually took part.

Started

May 2022

Finished

Oct 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients undergoing coronary artery bypass grafting surgery at the Department of Cardiac and Thoracic Surgery of the Clinic for Surgery, Clinical Hospital Center Osijek.

Ages

65 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients undergoing coronary artery bypass graft surgery to treat coronary artery disease * two or more coronary bypass surgery with the use of extracorporeal circulation * patients between the ages of 65 and 80 * patients according to the classification of the American Society of Anesthesiologists (ASA) classified in groups III and IV * patients who agreed to participate in the research and signed an informed consent Exclusion Criteria: * patients with communication difficulties (severe visual, hearing and speech impairment) * illiterate patients * patients with a history of dementia, schizophrenia, Parkinson's disease, Alzheimer's disease, alcoholism * patients with previously known liver failure of any grade according to the Child-Pough classification * patients with previously known renal failure greater than grade 2 * patients taking immunosuppressive, corticosteroid and anticholinergic therapy * intraoperatively used cell-saver and/or hemofilter * patients in whom the planned procedure is not performed * patients in whom it is not possible to assess cognitive functions postoperatively (patients sedated due to intra- or postoperative surgical complications)

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction coronary artery disorder Inflammation nervous system disorder Neuroinflammatory Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Cognitive Complications Postoperative Complications psychiatric disorder Systemic Inflammatory Response Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biomarkers Coronary artery bypass surgery Interleukin-6 Micrornas Postoperative cognitive complications Systemic inflammatory response syndrome

Contacts and locations

Locations

  • University Hospital Osijek

    Osijek, 31000, Croatia

More trials for these conditions

Other studies related to the condition(s) this trial covers.