Could a rice germ extract slow aging at the cellular level?
NCT ID NCT07675200
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study tests whether a daily dietary supplement called Miricell, made from rice germ extract rich in spermidine, can improve markers of healthy aging in adults aged 40 to 70. Participants take either the supplement or a placebo for 12 weeks, and researchers measure changes in autophagy (the body's cell-recycling process), brain health, metabolism, and visible signs of aging. The goal is to see if this natural compound can support healthier aging without causing side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Miricell (spermidine from rice germ extract)
- What this could lead to
- If it works, this could point toward a simple dietary supplement that supports healthy aging by boosting the body's natural cell-recycling process.
- What could go wrong
- This is a small, early-stage trial with only 70 participants, so results may not apply broadly. The supplement may show no benefit over a placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
INCLUSION CRITERIA: * Provide voluntary signed and dated informed consent. * Be in fair health as determined by medical history and routine blood chemistries. * Age between the ages of 40 and 70 (inclusive). * Body weight of at least 110 pounds. * Normotensive (seated, resting systolic blood pressure \<140 mm Hg and diastolic blood pressure \< 90 mm Hg. If the first measurement is slightly elevated above these limits, the subject will be given a brief (5-minute) rest period, and two more measurements will be taken. The average of all three measurements will be used to determine eligibility. * Normal seated, resting heart rate (\<90 per minute). * Willing to duplicate their previous 24-hour diet, refrain from alcohol for 24 hours, exercise for 24 hours prior to each trial, caffeine for 12 hours prior to each trial, and fast for 10 hours prior to each of the treatments. * Participant agrees to maintain existing dietary and physical activity patterns throughout the study period. * Participant is willing and able to comply with the study protocol. * If a dietary supplement was initiated within the past month, the participant is willing to discontinue supplement use followed by a 2-week washout prior to participation in the study. * Able to provide an adequate blood draw. EXCLUSION CRITERIA: * Use of probiotics, postbiotics or antibiotics within the past month. * A history of unstable or new-onset cardiovascular/cardiorespiratory, liver, or renal disease. * The participant's alcohol consumption is more than two standard alcoholic drinks per day or more than 10 drinks per week or has a history of drug/alcohol abuse or dependence. * History of diabetes (any form) or any endocrine disorder. * Fasting blood sugar of \> 125 mg/dL. * Current smokers who smoke 11 or more cigarettes per day (i.e. light smokers will be enrolled if they meet all other criteria). * History of hyperparathyroidism or an untreated thyroid disease. * History of malignancy in the previous five years except for non-melanoma skin cancer (basal cell cancer or squamous cell cancer of the skin). * Chronic inflammatory condition or disease (e.g., rheumatoid arthritis, Crohn's Disease, ulcerative colitis, lupus, HIV/AIDS, etc.). * Previous medical diagnosis of gout or fibromyalgia. * Any female who is pregnant, trying to become pregnant, is less than/or equal to 120 days postpartum, or any current women who are nursing. * Women who participate in this study must agree to the use of contraception for the duration of the study, and any sexually active woman will have to take a negative pregnancy test prior to enrolling. Women of childbearing age (any woman prior to menopause), regardless of their use of contraception, will be provided a urine pregnancy test kit at their screening visit and take the test in private using the female lavatory after signing an informed consent. * Known allergy or sensitivity to any ingredient in the test formulations as listed on the product label. * Any other diseases or conditions that, in the opinion of the medical staff, could confound the primary endpoints or place the subject at increased risk of harm if they were to participate.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The Center for Applied Health Sciences
RECRUITINGCanfield, Ohio, 44406, United States
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