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Blood pressure drug may help kids with rare genetic condition

NCT ID NCT00876200

Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether minoxidil, a blood pressure medicine, can improve blood vessel health in children with Williams-Beuren syndrome. The condition causes weak blood vessels due to a missing gene. 21 children took minoxidil or a placebo for 12 months, and researchers measured changes in artery thickness and stiffness. The goal was to see if the drug could prevent or reduce heart and blood vessel problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

21 people

The number who actually took part.

Start date

Mar 2009

Finished

Aug 2015

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * proven diagnosis of Williams Beuren syndrome (genetic test) * normotension or hypertension, treated or not * male or female, * 6\< age \<18, * negative pregnancy test for childbearing potential female * effective birth control for sexually active female * signed consent form collected from parents or legal guardian Exclusion Criteria: * pulmonary hypertension secondary to mitral stenosis * myocardial infarction within 1 month prior randomization * known allergies to minoxidil or any of the components of Lonoten. * asthma * renal failure (creatinine clearance \<40ml/min) * no affiliation to a national health insurance program (social security) * intolerance to lactose * current vasodilator anti hypertensive treatment

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Conditions

The condition(s) this trial relates to.

Cardiovascular Abnormalities Williams syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Williams beuren syndrome

Contacts and locations

Locations

  • Département de Pédiatrie, Hôpital Femme Mère Enfant

    Bron, 69677, France

  • Département de Pédiatrie- Service de Cardiologie, CHU Grenoble

    Grenoble, 38043, France

  • Service Cardiologie, CHU St Jacques

    Clermont-Ferrand, 63000, France

  • Service de Cardiologie - Hôpital des Enfants

    Toulouse, 31059, France

  • Service de Cardiologie Infantile, CHU Nancy

    Nancy, 54511, France

  • Service de Cardiologie Pédiatrique, CHU Angers

    Angers, 49033, France

  • Service de Cardiologie Pédiatrique, Hôpital Cardiovasculaire L. Pradel

    Bron, 69677, France

  • Service de Cardiologie Pédiatrique, Hôpital Necker Enfants Malades

    Paris, 75015, France

  • Service de Cardiologie, Hôpital Saint-André, CHU Bordeaux

    Bordeaux, 33075, France

  • Service de Génétique Médicale, CHU La Milétrie

    Poitiers, 86021, France

  • Service de Génétique Médicale, Hôpital Pellegrin, CHU Bordeaux

    Bordeaux, France

  • Service de Néphrologie Pédiatrique - Hôpital des Enfants, CHU Toulouse

    Toulouse, 31059, France

  • Service de Néphrologie Pédiatrique, CHRU de Lille

    Lille, 59000, France

  • Service de Néphrologie Pédiatrique, Hôpital Pellegrin, CHU Bordeaux

    Bordeaux, 33076, France

  • Service de Pathologie Cardiaque Congénitale du Fœtus, de l'Enfant et de l'Adulte, Hôpital Haut Lévêque, CHU de Bordeaux

    Pessac, 33604, France

  • Service de Physiologie, Explorations Fonctionnelles, Hôpital Robert Debré

    Paris, 75019, France

  • Service des Maladies Cardiovasculaires Infantiles et Congénitales, CHRU Lille

    Lille, 59000, France

  • Unité de Pharmacologie Clinique, Hôpital Robert Debré

    Paris, 75019, France

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