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Can mindfulness or brain zaps lift Late-Life depression?

NCT ID NCT07186023

Symptom relief Sponsor: National Health Research Institutes, Taiwan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether mindfulness programs or a brain stimulation device can improve mood and thinking in older adults with depression. Researchers will track brain activity and well-being over time. The goal is to find safe, non-drug ways to help seniors feel better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mindfulness-based programs and brain stimulation device
What this could lead to
If successful, this could point toward effective non-drug treatments for depression in older adults, improving mental health without medication.
What could go wrong
This is an early-stage study with only 124 participants, so results may not apply to everyone. The interventions require time and commitment, and brain changes may not translate to lasting symptom relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 124 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for individuals participating in mindfulness-based Interventions: * Literate or have received an education above the elementary level. * Have normal or corrected vision and hearing, able to communicate and understand explanations. * Right-handed individuals as assessed by the Edinburgh Handedness Inventory. Exclusion Criteria for individuals participating in mindfulness-based Interventions: * Individuals with dementia, stroke, cerebrovascular disease, brain injury, epilepsy, or Parkinson's disease. * Individuals with neurological system disorders. * Individuals with alcohol or drug dependence. * Individuals with other major physical illnesses, such as diabetes, heart failure, or endocrine abnormalities, or those who have experienced an acute myocardial infarction within the past three months. * Individuals with metal objects in the body that cannot undergo magnetic resonance imaging (MRI), such as cardiac pacemakers, vascular clips, hearing aids, artificial joints, steel pins, etc. * Individuals with Claustrophobia. * Individuals in pregnancy or possibility of pregnancy. Inclusion Criteria for individuals participating in brain stimulation Intervention: * Individuals diagnosed with major depressive disorder by psychiatrists according to the Diagnostic and Statistical Manual, and who can cooperate with the psychiatric outpatient clinic regulations. * Literate or have received an education above the elementary level. * Have normal or corrected vision and hearing, able to communicate and understand explanations. * Right-handed individuals as assessed by the Edinburgh Handedness Inventory. * Individuals are prescribed brain stimulation therapy by clinical physicians. Exclusion Criteria for individuals participating in brain stimulation Intervention: * Individuals with dementia, stroke, cerebrovascular disease, brain injury, epilepsy, or Parkinson's disease. * Individuals with neurological system disorders. * Individuals with alcohol or drug dependence. * Individuals with other major physical illnesses, such as diabetes, heart failure, or endocrine abnormalities, or those who have experienced an acute myocardial infarction within the past three months. * Individuals with metal objects in the body that cannot undergo magnetic resonance imaging (MRI), such as cardiac pacemakers, vascular clips, hearing aids, artificial joints, steel pins, etc. * Individuals with Claustrophobia. * Individuals in pregnancy or possibility of pregnancy.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain stimulation intervention Late life depression Late-life adults Late-life prodromal depression Mindfulness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Center for Geriatrics and Welfare Research

    NOT_YET_RECRUITING

    Yunlin, 632007, Taiwan

  • Shuang Ho Biomedical Park, Taipei Medical University

    RECRUITING

    New Taipei City, 235603, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.