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Milk protein showdown: does A1-Free milk beat conventional for blood sugar?

NCT ID NCT07567443

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares how A1-free milk (only A2 protein) and conventional milk (both A1 and A2 proteins) affect blood sugar and insulin levels after eating. Thirty-five healthy adults will drink different milk beverages across four visits, with blood samples taken over several hours. The goal is to see if milk protein type influences metabolism and digestion.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A1-free milk (A2 milk) and conventional milk (A1/A2 milk)
What this could lead to
If it works, this could help people choose milk types that better manage blood sugar and insulin responses after eating.
What could go wrong
This is a small, early-stage study in healthy adults only, so results may not apply to people with diabetes or other conditions. It's not testing a treatment or cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 35 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ability/desire to provide informed consent * Are between 18 and 65 years of age * Are generally healthy, with no known metabolic or gastrointestinal conditions that would affect digestion or metabolism * Are willing to consume milk-based beverages and lactose-containing drinks as part of the study * Are willing to fast overnight (approximately 10-12 hours) prior to study visits and follow study instructions (e.g., diet and activity restrictions) * Are willing to attend all study visits and complete all study procedures (blood draws, breath tests, urine samples, questionnaires) * Are able to understand and provide written informed consent in English. Exclusion Criteria: * You have a known allergy to milk or dairy products * You are currently pregnant, planning to become pregnant, or breastfeeding * You currently smoke or have used tobacco or nicotine-containing products within the past 3 months * You have a history of excessive alcohol use within the past 30 days * You have been diagnosed with diabetes (Type 1 or Type 2), prediabetes, or other metabolic conditions that affect glucose or insulin responses (such as insulin resistance, metabolic syndrome, or polycystic ovary syndrome \[PCOS\]) * You have a history of gastrointestinal conditions that may affect digestion or absorption (such as inflammatory bowel disease, Crohn's disease, ulcerative colitis, celiac disease, or severe irritable bowel syndrome) * You have had gastrointestinal surgery that alters normal digestive function (such as bariatric surgery or gastric bypass) * You have other medical conditions that may affect digestion or interfere with study results (such as Past or present: Organ transplant, chronic pancreatitis, pancreatic insufficiency, symptomatic biliary disease, Celiac disease, chronic constipation, diverticulosis, inflammatory bowel disease (IBD), ulcerative colitis (UC), Crohn's disease (CD), small intestine bacterial overgrowth syndrome (SIBO), gastroparesis, gastro-esophageal reflux disease (GERD), Irritable Bowel Syndrome (IBS) or any other medical condition with symptoms that could confound collection of adverse events.) * You have used medications or supplements known to affect glucose metabolism, digestion, or gastrointestinal function within the following timeframes prior to enrollment: * Within 4 weeks: insulin, metformin, GLP-1 receptor agonists, corticosteroids, digestive enzymes, fiber supplements, and all oral or IV antibiotics * Within 2 weeks: bismuth-containing compounds (e.g., Pepto-Bismol) and proton pump inhibitors or acid suppressors (e.g., omeprazole \[Prilosec\], lansoprazole \[Prevacid\], esomeprazole \[Nexium\], pantoprazole \[Protonix\], rabeprazole \[Aciphex\]) * Within 1 week: laxatives and stool softeners (e.g., Miralax, Colace, senna, lactulose, Citrucel, Metamucil, Fibercon), probiotics and prebiotics, gastrointestinal motility agents (e.g., Reglan, Linzess, Amitiza), and antidiarrheal medications (e.g., loperamide \[Imodium\], Lomotil) * You have had a recent infection within the past 30 days * You have been diagnosed with Human Immunodeficiency Virus (HIV), hepatitis B, or hepatitis C * You are currently undergoing chemotherapy * Height: \_\_\_ Weight: \_\_\_ BMI: \_\_\_ Weighing \<16.5 kg or Body mass index \> 35 kg/m2 * You have participated in another clinical trial or used an investigational product within the past 30 days * You have any other condition that, as determined by the study team, would make participation unsafe or interfere with study results

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