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Zap your memory? scalp stimulation trial aims to fight forgetfulness

NCT ID NCT05289804

Symptom relief Sponsor: University of Dublin, Trinity College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a non-invasive electrical stimulation device on the scalp in 80 adults aged 50+ with mild cognitive impairment. Participants learned word pairs while receiving either real or sham stimulation. Their memory was tested right after, and again at 7 and 28 days. The goal was to see if the stimulation could reduce long-term forgetting.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-invasive electrical stimulation of the scalp
What this could lead to
If it works, this could point toward a simple, drug-free way to boost memory in people with mild cognitive impairment.
What could go wrong
This is an early-phase study with only 80 participants. The effect may be small or not last, and the stimulation might not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

80 people

The number who actually took part.

Started

Sep 2022

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥50 years * Diagnosis of probable aMCI or mild AD * Montreal Cognitive Assessment between 18-25 * Mini Mental State Examination score \>21 * Stable AChl medication \>3 months * Adequate visual and auditory acuity * Capacity to understand and sign informed consent Exclusion Criteria: * Any cause of cognitive decline or dementia that is not Alzheimer's disease related including parkinsonism related dementias, vascular dementia, fronto-temporal dementia. * Enrolment in an ongoing investigational medicinal product study * History in the past 2 years of epileptic seizures * Any current major psychiatric disorder * Evidence of brain damage, including significant trauma, stroke, hydrocephalus, intellectual disability, or serious neurological disorder. * History of alcoholism or drug abuse within the last 12 months * Medical devices not eligible for MRI scanning

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction Memory Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Memory disorders in old age Memory impairment Mild cognitive impairment

Contacts and locations

Locations

  • TCIN

    Dublin, Dublin 2, Ireland

More trials for these conditions

Other studies related to the condition(s) this trial covers.