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Scientists investigate why inflammation worsens with age

NCT ID NCT05392582

Knowledge-focused Sponsor: University of Utah Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how immune cells and inflammation change as we age. Researchers will compare healthy younger adults (18-35) and older adults (65+) by measuring blood markers, glucose tolerance, and leg strength. The goal is to understand chronic inflammation better so that future treatments can be designed to reduce it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal new targets for therapies that reduce chronic inflammation in older adults.
What could go wrong
This is a small observational study, not a treatment trial. It may not lead directly to new therapies, and findings may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy young and older adults

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 18 - 35y; 65y and older 2. BMI: \<30 kg/m2 3. Ability to sign informed consent 4. For older participant group: Clinical Frailty Scale score \< 3 and Mini-Cog score \> 3 5. Good general medical health, ambulatory and in independent living setting Exclusion Criteria: * History of cardiovascular disease (e.g., CHF, CAD, MI, CVA) * History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted) * History of kidney disease or failure (CKD \> stage 4) * History of vascular disease * Uncontrolled hypertension - Elevated systolic pressure \>150 or a diastolic blood pressure \> 100 * Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma * Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted) * Chronic anti-inflammatory medication use (≥ 2 weeks) within 4 weeks of enrollment * Chronic inflammatory conditions (e.g., Rheumatoid Arthritis, Crohn's, fibromyalgia, lupus, colitis) HIV, Hepatitis B and C * History of stroke with motor disability * A recent history (\<12 months) of GI bleed * History of liver disease or AST/ALT 2 times above the normal limit * History of respiratory disease (acute upper respiratory infection, history of chronic lung disease) * Current smokers or current tobacco use * Current pregnancy as determined by positive pregnancy test * Any staff members who report directly to the principal investigators.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic inflammation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The University of Utah

    RECRUITING

    Salt Lake City, Utah, 84112, United States

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