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Tiny plastics found in heart Arteries—What does it mean for your health?

NCT ID NCT07291609

Knowledge-focused Sponsor: Azienda Ospedaliera "Sant'Andrea" Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks for micro- and nanoplastics in the blood of the heart's arteries in 120 people with chronic coronary syndrome. Participants will have a standard heart CT and an angiogram, and a small blood sample from the heart will be tested for plastic particles. The goal is to see if the amount of plastic in the blood is linked to the amount of plaque in the arteries. This is an observational study—it does not test any treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal whether microplastics in heart arteries are linked to plaque buildup, pointing to pollution as a possible heart disease risk factor.
What could go wrong
This is an observational study, not a treatment trial. It only measures and correlates—it cannot prove that microplastics cause heart disease. Results may not lead to any direct medical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Consecutive patients undergoing coronary CT angiography (CCTA) for suspected or known chronic coronary syndromes (CCS) referred to invasive coronary angiography for clinical indication.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: ALL the following: 1. Age \> 18 years old; 2. Suspected or known chronic coronary syndromes undergoing coronary CT angiography; 3. Clinical indication to invasive coronary angiography; 4. Able to give informed consent. Exclusion Criteria: 1. Coronary CT angiography not available; 2. Poor quality CCTA; 3. Absence of native coronary stenosis \>=50% at CCTA; 4. Contraindications to invasive coronary angiography and percutaneous coronary intervention 5. Life expectancy \< 1 year due to non-cardiac pathology

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic coronary syndrome Computed tomography Coronary artery disease Coronary plaque Microplastics Nanoplastics Pollution; exposure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Azienda Ospedaliera Integrata Verona, Italy

    RECRUITING

    Verona, Italy

  • Cardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy.

    NOT_YET_RECRUITING

    Forlì, Italy

  • Centro Cardiologico Monzino

    ACTIVE_NOT_RECRUITING

    Milan, Italy

  • Department of Advanced Medical and Surgical Sciences, University of Campania-Luigi Vanvitelli, Naples, Italy.

    ACTIVE_NOT_RECRUITING

    Naples, Italy

  • Division of Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", Caserta, Italy.

    NOT_YET_RECRUITING

    Caserta, Italy

  • Sant'Andrea University Hospital

    RECRUITING

    Roma, Italy

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