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Could a brother or son’s cells affect pregnancy loss?

NCT ID NCT05340556

Knowledge-focused Sponsor: Caroline Nørgaard-Pedersen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This pilot study examines whether cells from a woman’s firstborn son or older brother can be found in her blood and if they are linked to recurrent pregnancy loss. Researchers will take blood and cheek swab samples from 32 women who have had at least three miscarriages. The goal is to gather information for a larger future study, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help understand why some women experience recurrent pregnancy loss, potentially pointing toward future diagnostic or treatment approaches.
What could go wrong
This is a very small pilot study (32 participants) that only looks for cells in the blood, not a treatment. It may not find a clear link or lead to any practical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

32 people

The number who actually took part.

Started

Apr 2022

Finished

Feb 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

sRPL patient (proband): Inclusion Criteria: * ≥3 consecutive pregnancy losses ≤12 weeks of gestation, which do not include confirmed ectopic or molar pregnancies. * Age \<41 years at time of admission * Patients who have minimum one alive older brother with a common mother and prior birth of a boy, and patients who have minimum one alive older brother with a common mother and prior birth of a girl. Exclusion Criteria: * Significant intrauterine malformations * Thyroid dysfunction * Known chromosomal abnormality * An older brother, a son or a daughter from whom we cannot not collect a swab test e.g., due to lack of consent, death, distance etc. * Transplant recipient * Transfusion recipient * Pregnancy at the time the blood sample is collected Older Brother: Inclusion Criteria: * Age difference between proband and the older brother \<15 years * Common mother with the proband sRPL patient's child: Inclusion Criteria: * Age \<15 years

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Conditions

The condition(s) this trial relates to.

habitual spontaneous abortion pregnancy loss, recurrent, susceptibility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Recurrent pregnancy loss, not pregnant

Contacts and locations

Locations

  • Aalborg University Hospital

    Aalborg, 9000, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.